Biohybrid Actuators for Soft Robotics: Challenges in Scaling Up

被引：38
作者：
Won, Phillip [1 ,2 ]
Ko, Seung Hwan [2 ]
Majidi, Carmel [1 ,3 ,4 ]
Feinberg, Adam W. [3 ,4 ]
Webster-Wood, Victoria A. [3 ]
机构：
[1] Carnegie Mellon Univ, Dept Mech Engn, Pittsburgh, PA 15213 USA
[2] Seoul Natl Univ, Dept Mech Engn, Seoul 08826, South Korea
[3] Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA
[4] Carnegie Mellon Univ, Dept Mat Sci & Engn, Pittsburgh, PA 15213 USA
来源：
ACTUATORS | 2020年 / 9卷 / 04期
基金：
美国安德鲁·梅隆基金会; 新加坡国家研究基金会;
关键词：
biohybrid actuators; soft robotics; biohybrid robots; tissue engineering; STIMULATION; RECOVERY; 2D;
D O I：
10.3390/act9040096
中图分类号：
TH [机械、仪表工业];
学科分类号：
0802 ;
摘要：
Living systems have evolved to survive in a wide range of environments and safely interact with other objects and organisms. Thus, living systems have been the source of inspiration for many researchers looking to apply their mechanics and unique characteristics in engineering robotics. Moving beyond bioinspiration, biohybrid actuators, with compliance and self-healing capabilities enabled by living cells or tissue interfaced with artificial structures, have drawn great interest as ways to address challenges in soft robotics, and in particular have seen success in small-scale robotic actuation. However, macro-scale biohybrid actuators beyond the centimeter scale currently face many practical obstacles. In this perspective, we discuss the challenges in scaling up biohybrid actuators and the path to realize large-scale biohybrid soft robotics.
引用
收藏
页码：1 / 11
页数：11
相关论文
共 53 条
[1]   Living Materials Herald a New Era in Soft Robotics [J].
Appiah, Clement ;
Arndt, Christine ;
Siemsen, Katherina ;
Heitmann, Anne ;
Staubitz, Anne ;
Selhuber-Unkel, Christine .
ADVANCED MATERIALS, 2019, 31 (36)
[2]   Laser-based three-dimensional multiscale micropatterning of biocompatible hydrogels for customized tissue engineering scaffolds [J].
Applegate, Matthew B. ;
Coburn, Jeannine ;
Partlow, Benjamin P. ;
Moreau, Jodie E. ;
Mondia, Jessica P. ;
Marelli, Benedetto ;
Kaplan, David L. ;
Omenetto, Fiorenzo G. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (39) :12052-12057
[3]   Neuromuscular actuation of biohybrid motile bots [J].
Aydin, Onur ;
Zhang, Xiaotian ;
Nuethong, Sittinon ;
Pagan-Diaz, Gelson J. ;
Bashir, Rashid ;
Gazzola, Mattia ;
Saif, M. Taher A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (40) :19841-19847
[4]   A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction [J].
Bakooshli, Mohsen Afshar ;
Lippmann, Ethan S. ;
Mulcahy, Ben ;
Iyer, Nisha ;
Nguyen, Christine T. ;
Tung, Kayee ;
Stewart, Bryan A. ;
van den Dorpel, Hubrecht ;
Fuehrmann, Tobias ;
Shoichet, Molly ;
Bigot, Anne ;
Pegoraro, Elena ;
Ahn, Henry ;
Ginsberg, Howard ;
Zhen, Mei ;
Ashton, Randolph Scott ;
Gilbert, Penney M. .
ELIFE, 2019, 8
[5]   Bridging functional nanocomposites to robust macroscale devices [J].
Begley, Matthew R. ;
Gianola, Daniel S. ;
Ray, Tyler R. .
SCIENCE, 2019, 364 (6447) :1250-+
[6]   Unraveling the Role of Mechanical Stimulation on Smooth Muscle Cells: A Comparative Study Between 2D and 3D Models [J].
Bono, N. ;
Pezzoli, D. ;
Levesque, L. ;
Loy, C. ;
Candiani, G. ;
Fiore, G. B. ;
Mantovani, D. .
BIOTECHNOLOGY AND BIOENGINEERING, 2016, 113 (10) :2254-2263
[7]  
Cerchiari A, 2015, TISSUE ENG PART C-ME, V21, P541, DOI [10.1089/ten.tec.2014.0450, 10.1089/ten.TEC.2014.0450]
[8]   Biomedical applications of soft robotics [J].
Cianchetti, Matteo ;
Laschi, Cecilia ;
Menciassi, Arianna ;
Dario, Paolo .
NATURE REVIEWS MATERIALS, 2018, 3 (06) :143-153
[9]   Modeling Development and Disease with Organoids [J].
Clevers, Hans .
CELL, 2016, 165 (07) :1586-1597
[10]   A 3D-printed platform for modular neuromuscular motor units [J].
Cvetkovic, Caroline ;
Rich, Max H. ;
Raman, Ritu ;
Kong, Hyunjoon ;
Bashir, Rashid .
MICROSYSTEMS & NANOENGINEERING, 2017, 3
123456