The H-1 NMR Spectrum game, the first example of a team-based tabletop game focused on elucidating the structures of organic small molecules using H-1 NMR spectra, was developed and deployed in a college-level organic chemistry lecture course and laboratory course. The tabletop game was designed as a collaborative and competitive group activity to encourage multiple rounds of play to help students reinforce their H-1 NMR spectra interpretation skills. While playing in either team-based or free-forall mode, students analyzed the provided chemical shifts, splitting patterns, integrations, and molecular formula within a designated time limit to correctly deduce the structure associated with the H-1 NMR spectrum. After playing the game, students in a lecture course and a laboratory course self-reported that they felt more comfortable solving H-1 NMR spectroscopy questions, found the game to be an appealing study aid, and were able to complete multiple rounds of play to strengthen their skills in interpreting H-1 NMR spectra. The H-1 NMR Spectrum tabletop game may serve as an engaging and competitive group learning tool to supplement teaching on H-1 NMR spectroscopy.