Both the HLA-DPB1 and-DRB1 alleles correlate with risk for multiple sclerosis in Japanese: clinical phenotypes and gender as important factors

被引:53
作者
Fukazawa, T
Yamasaki, K
Ito, H
Kikuchi, S
Minohara, M
Horiuchi, I
Tsukishima, E
Sasaki, H
Hamada, T
Nishimura, Y
Tashiro, K
Kira, J
机构
[1] Hokuyukai Neurol Hosp, Nishi Ku, Sapporo, Hokkaido 0630802, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Inst Neurol, Dept Neurol, Fukuoka 812, Japan
[3] Kumamoto Univ, Grad Sch Med Sci, Dept Neurosci & Immunol, Div Immunogenet, Kumamoto, Japan
[4] Hokkaido Univ, Grad Sch Med, Dept Neurol, Sapporo, Hokkaido, Japan
来源
TISSUE ANTIGENS | 2000年 / 55卷 / 03期
关键词
HLA-DPB1; HLA-DRB1; gender effect; multiple sclerosis; disease susceptibility; optico-spinal MS; Japanese;
D O I
10.1034/j.1399-0039.2000.550302.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The purpose of this study was to clarify the association of HLA-DRB1 and -DPB1 alleles with multiple sclerosis (MS) in Japanese, to determine whether optico-spinal MS (OS-MS) and conventional MS are immunogenetically distinct, and to verify the role of gender difference in HLA associations of MS. We studied HLA-DRB1 and -DPB1 polymorphisms in 166 Japanese patients with MS. Forty-seven patients were classified as having the optico-spinal MS (OS-MS) and 119 as having conventional MS. A lack of DPB1*0301 and a higher frequency of DFB1*0501 compared with controls (corrected P < 0.0074; odds ratio = 9.48) were found in OS-MS. By contrast, we found for the first time an association of DPB1*0301 with conventional MS in Japanese (corrected P = 0.0444; odds ratio = 3.28), Logistic analysis, adjusted for sex and age, revealed independent associations of DPB1*0301 (P = 0.0004, adjusted odds ratio (aOR) = 4.70), DPB1*0501 (P = 0.0081, aOR = 2.50) and DRB1*1501 (P = 0.0252 aOR = 2.21) with conventional MS. the frequencies of DRB1*1501 and DPB1*0501 in male patients with conventional MS were equal to those in male controls while the DPB1*0301 frequency was increased in both male and female patients. We did not find any association of these HLA alleles with disease course and severity. In conclusion, OS-MS is a DPB1*0501-associated distinct subtype of MS, and DPB1*0301 is the most strongly associated allele with conventional MS in Japanese. In addition, gender plays an important role in HLA association with MS.
引用
收藏
页码:199 / 205
页数:7
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