Increased platelet reactivity in patients given Orbofiban after an acute coronary syndrome:: An OPUS-TIMI 16 substudy

被引：75
作者：
Holmes, MB
Sobel, BE
Cannon, CP
Schneider, DJ
机构：
[1] Univ Vermont, Coll Med, Cardiol Unit, Dept Med, Burlington, VT 05401 USA
[2] Brigham & Womens Hosp, Cambridge, MA USA
[3] Harvard Univ, Sch Med, Cambridge, MA 02138 USA
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 85卷 / 04期
关键词：
D O I：
10.1016/S0002-9149(99)00778-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The results of the present study underscore the potential value of the use of sensitive assays of specific aspects of platelet function for identifying and quantifying changes in platelet reactivity after initiation of therapy with antiplatelet agents. Implementation of such assays could contribute to optimal design and performance of clinical trials of antiplatelet agents as well as treatment of patients with acute coronary syndromes.
引用
收藏
页码：491 / 493
页数：3
相关论文
共 13 条
  • [1] Platelet activation in patients after an acute coronary syndrome: Results from the TIMI-12 trial
    Ault, KA
    Cannon, CP
    Mitchell, J
    McCahan, J
    Tracy, RP
    Novotny, WF
    Reimann, JD
    Braunwald, E
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (03) : 634 - 639
  • [2] Bazzino O, 1998, NEW ENGL J MED, V338, P1488
  • [3] USE OF A MONOCLONAL-ANTIBODY DIRECTED AGAINST THE PLATELET GLYCOPROTEIN IIB/IIIA RECEPTOR IN HIGH-RISK CORONARY ANGIOPLASTY
    CALIFF, RM
    SHADOFF, N
    VALETT, N
    BATES, E
    GALEANA, A
    KNOPF, W
    SHAFTEL, J
    BENDER, MJ
    AVERSANO, T
    RAQUENO, J
    GURBEL, P
    COWFER, J
    COHEN, M
    CROSS, P
    BITTL, J
    EDDINGS, K
    TAYLOR, M
    DEROSA, K
    HATTEL, L
    COOPER, L
    ESHELMAN, B
    FINTEL, D
    NIEMYSKI, P
    KLEIN, L
    KENNEDY, H
    THORNTON, T
    KEREIAKES, D
    MARTIN, L
    ANDERSON, L
    HIGBY, N
    ELLIS, S
    BREZINA, K
    GEORGE, B
    CHAPEKIS, A
    SMITH, D
    ANWAR, A
    GERBER, TL
    PRITCHARD, GL
    MYLER, R
    SHAW, R
    MURPHY, M
    WARD, K
    MADIGAN, NP
    BLANKENSHIP, J
    HALBERT, M
    FLANAGAN, C
    TANNENBAUM, M
    POLICH, M
    STEVENSON, C
    TCHENG, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (14) : 956 - 961
  • [4] The lack of augmentation by aspirin of inhibition of platelet reactivity by Ticlopidine
    Farrell, TP
    Hayes, KB
    Sobel, BE
    Schneider, DJ
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (05) : 770 - 774
  • [5] Ferguson JJ, 1999, CIRCULATION, V100, P570, DOI 10.1161/01.CIR.100.6.570
  • [6] FRELINGER AL, 1991, J BIOL CHEM, V266, P17106
  • [7] Differences between activation thresholds for platelet P-selectin and glycoprotein IIb-IIIa expression and their clinical implications
    Holmes, MB
    Sobel, BE
    Howard, DB
    Schneider, DJ
    [J]. THROMBOSIS RESEARCH, 1999, 95 (02) : 75 - 82
  • [8] Variable responses to inhibition of fibrinogen binding induced by Tirofiban and Eptifibatide in blood from healthy subjects
    Holmes, MB
    Sobel, BE
    Schneider, DJ
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1999, 84 (02) : 203 - 207
  • [9] Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (αIIbβ3) inhibitors
    Peter, K
    Schwarz, M
    Ylänne, J
    Kohler, B
    Moser, M
    Nordt, T
    Salbach, P
    Kübler, W
    Bode, C
    [J]. BLOOD, 1998, 92 (09) : 3240 - 3249
  • [10] Blood clotting in minimally altered whole blood
    Rand, MD
    Lock, JB
    vantVeer, C
    Gaffney, DP
    Mann, KG
    [J]. BLOOD, 1996, 88 (09) : 3432 - 3445
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