5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Underlying Pediatric Cancers

被引：2
作者：
Jhanwar, Shalu [1 ,2 ]
Deogade, Ajinkya [2 ,3 ]
机构：
[1] Univ Basel, Dept Biomed, Dev Genet, CH-4058 Basel, Switzerland
[2] Univ Pompeu Fabra, Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona 08003, Spain
[3] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
来源：
EPIGENOMES | 2019年 / 3卷 / 02期
关键词：
epigenetics; DNA methylation; pediatric cancer; 5mC; 5hmC; acute lymphoblastic leukaemia; neuroblastoma; ACUTE LYMPHOBLASTIC-LEUKEMIA; POOR PROGNOSTIC-FACTOR; DNA METHYLATION; PROMOTER METHYLATION; MAMMALIAN DNA; HYPOMETHYLATION; METHYLOME; REVEALS; GENOME; DEHYDROGENASE;
D O I：
10.3390/epigenomes3020009
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is an urgent need to study the mechanisms contributing to the pathogenicity of pediatric cancer. Over the past decades, next-generation sequencing (NGS) has enabled us to perform genome-wide screening to study the complex regulatory mechanisms of 5mC and 5hmC underlying pediatric tumorigenesis. To shed light on recent developments on pediatric cancer predisposition and tumor progression, here we discuss the role of both genome-wide and locus-specific dysregulation of 5mC and 5hmC in hematopoiesis malignancy and neuroblastoma, the most common types of pediatric cancer, together with their therapeutic potential.
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页数：6
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