Antitumor Activity and DNA-Binding Investigations of the Zn(II) and Cu(II) Complexes with Isoeuxanthone

被引：8
|
作者：
Wang, Huifang [1 ]
Shen, Rui [2 ]
Wu, Jincai [1 ]
Tang, Ning [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 08期
基金：
美国国家科学基金会;
关键词：
isoeuxanthone; Zn(II) complex; Cu(II) complex; DNA-binding; intercalative mode; antitumor activity; RUTHENIUM(II) COMPLEXES; XANTHONE DERIVATIVES; INHIBITORS; SENSITIZATION; ANTIOXIDANT; MANGIFERIN;
D O I：
10.1248/cpb.57.814
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new complexes ZnL2 (1) and CuL2 (2) (here, HL=isoeuxanthone) have been synthesized and characterized by elemental analyses, molar conductance, infrared spectra (IR), H-1-NMR and UV-Vis measurements. The interactions of them with calf thymus DNA (ct DNA) have been investigated by absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy and viscosity measurements. Experimental results revealed an intercalative interaction with DNA for the complexes; furthermore the binding affinity of 2 is higher than that of I according to the calculated binding constant values. In addition, they were evaluated for their cytotoxic activities toward human esophageal cancer (ECA109) and human gastric cancer (SGC7901) cells by MTT assay. Both of them showed significant cytotoxic potency.
引用
收藏
页码：814 / 818
页数：5
相关论文
共 50 条
  • [41] Syntheses, Crystal Structures and DNA-Binding Properties of Ni(II)/Zn(II)/Cd(II)/Cu(II) Complexes with 4-Methyl-1-((quinolin-8-ypmethylene)-thiosemicarbazide
    Mao Pan-Dong
    Han Xue-Feng
    Li Shan-Shan
    Shi Lin-Ping
    Wang Yuan
    Wu Wei-Na
    CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2017, 33 (04) : 692 - 698
  • [42] Synthesis and antitumor activity of DNA binding cationic porphyrin-platinum(II) complexes
    Song, R
    Kim, YS
    Lee, CO
    Sohn, YS
    TETRAHEDRON LETTERS, 2003, 44 (08) : 1537 - 1540
  • [43] The impact of spermine competition on the efficacy of DNA-binding Fe(II), Co(II), and Cu(II) complexes of dimeric chromomycin A3
    Lu, Wen-Je
    Wang, Hui-Min
    Yuann, Jeu-Ming P.
    Huang, Chun-Yu
    Hou, Ming-Hon
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2009, 103 (12) : 1626 - 1633
  • [44] Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents
    Wang, Chengxi
    Wu, Qiong
    Zeng, Yongchang
    Huang, Dongwei
    Yu, Chuqin
    Wang, Xicheng
    Mei, Wenjie
    JOURNAL OF COORDINATION CHEMISTRY, 2015, 68 (09) : 1489 - 1499
  • [45] Macrocyclic nickel(II) complexes: Synthesis, characterization, superoxide scavenging activity and DNA-binding
    Ramadan, Abd El-Motaleb M.
    JOURNAL OF MOLECULAR STRUCTURE, 2012, 1015 : 56 - 66
  • [46] DNA-binding and photocleavage, cytotoxicity, apoptosis and antioxidant activity studies of ruthenium(II) complexes
    Li Xu
    Yang-Yin Xie
    Nan-Jing Zhong
    Zhen-Hua Liang
    Juan He
    Hong-Liang Huang
    Yun-Jun Liu
    Transition Metal Chemistry, 2012, 37 : 197 - 205
  • [47] Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes
    Liu, Yun-Jun
    Zeng, Cheng-Hui
    Huang, Hong-Liang
    He, Li-Xin
    Wu, Fu-Hai
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) : 564 - 571
  • [48] In Vitro Cytotoxicity, Apoptosis, DNA-Binding, and Antioxidant Activity Studies of Ruthenium (II) Complexes
    Huang, Hong-Liang
    Liu, Yun-Jun
    Zeng, Cheng-Hui
    He, Li-Xin
    Wu, Fu-Hai
    DNA AND CELL BIOLOGY, 2010, 29 (05) : 261 - 270
  • [49] DNA-binding and photocleavage, cytotoxicity, apoptosis and antioxidant activity studies of ruthenium(II) complexes
    Xu, Li
    Xie, Yang-Yin
    Zhong, Nan-Jing
    Liang, Zhen-Hua
    He, Juan
    Huang, Hong-Liang
    Liu, Yun-Jun
    TRANSITION METAL CHEMISTRY, 2012, 37 (02) : 197 - 205
  • [50] Synthesis, DNA-binding, DNA-photonuclease profiling and antimicrobial activity of novel tetra-aza macrocyclic Ni(II), Co(II) and Cu(II) complexes constrained by thiadiazole
    Kumar, B. Vinay
    Naik, H. S. Bhojya
    Girija, D.
    Sharath, N.
    Pradeepa, S. M.
    Hoskeri, H. Joy
    Prabhakara, M. C.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 94 : 192 - 199
12345