Distant Recurrence Risk after Late Ipsilateral Breast Tumor Recurrence: Results of a Retrospective, Single-Institution Study

被引：2

作者：

Ishitobi, Makoto ^{[1
]}

Okuno, Jun ^{[1
]}

Kittaka, Nobuyoshi ^{[1
]}

Nakayama, Takahiro ^{[1
]}

Koyama, Hiroki ^{[1
]}

Tamaki, Yasuhiro ^{[1
]}

机构：

[1] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Breast & Endocrine Surg, Osaka 5378511, Japan

来源：

ONCOLOGY | 2015年 / 89卷 / 05期

关键词：

Breast cancer; Ipsilateral breast tumor recurrence; Late recurrence; SURGICAL ADJUVANT BREAST; 20-YEAR FOLLOW-UP; LOCAL RECURRENCE; CONSERVING TREATMENT; PROGNOSTIC-FACTORS; LOCOREGIONAL RECURRENCES; CANCER; THERAPY; IMPACT; MASTECTOMY;

D O I：

10.1159/000437440

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: There is limited information regarding risk factors for distant recurrence in patients with late ipsilateral breast tumor recurrence (IBTR). Methods: Late IBTR was defined as IBTR occurring >5 years after the initial surgery. Seventy-eight patients with late IBTR were reviewed to examine the risk factors of distant recurrence. Results: The negative estrogen receptor and positive HER2 statuses of IBTR were significantly correlated with poorer distant disease-free survival (p = 0.03 and 0.02, respectively). Multivariate analyses demonstrated that the HER2 status of IBTR was an independent predictive factor of distant recurrence (p = 0.04). Conclusions: The results of our retrospective, single-institution study revealed that the HER2 status of IBTR was an independent predictive factor of distant recurrence in patients with late IBTR. (C) 2015 S. Karger AG, Basel

引用

页码：269 / 274

页数：6

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