Neocortical neurogenesis in humans is restricted to development

被引：298
作者：
Bhardwaj, Ratan D.
Curtis, Maurice A.
Spalding, Kirsty L.
Buchholz, Bruce A.
Fink, David
Bjork-Eriksson, Thomas
Nordborg, Claes
Gage, Fred H.
Druid, Henrik
Eriksson, Peter S.
Frisen, Jonas [1 ]
机构：
[1] Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden
[2] Karolinska Inst, Dept Forens Med, SE-17177 Stockholm, Sweden
[3] Gothenburg Univ, Sahlgrenska Acad, Sect Clin Neurosci, Inst Neurosci & Physiol, SE-40530 Gothenburg, Sweden
[4] Lawrence Livermore Natl Lab, Ctr Accelerator Mass Spectrometry, Livermore, CA 94551 USA
[5] Australian Nucl Sci & Technol Org, Menai, NSW 2234, Australia
[6] Sahlgrens Univ Hosp, Dept Oncol, SE-41345 Gothenburg, Sweden
[7] Sahlgrens Univ Hosp, Dept Pathol, SE-41345 Gothenburg, Sweden
[8] Salk Inst Biol Studies, La Jolla, CA 92037 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 33期
关键词：
neocortex; stem cell;
D O I：
10.1073/pnas.0605177103
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of C-14, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.
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页码：12564 / 12568
页数：5
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