Manipulation of the tumor suppressor p53 for potentiating cancer therapy

被引：33

作者：

Haupt, S

Haupt, Y ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmaceut, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 04期

基金：

以色列科学基金会;

关键词：

p53; Mdm2; therapy; DNA damage; small molecules;

D O I：

10.1016/j.semcancer.2004.04.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor suppressor p53 is a linchpin in the regulation of appropriate cellular responses to various stress conditions. Inactivation of the functions of this critical participant can have diabolical consequences, in particular the development of malignant diseases. Elicitation of appropriate p53 functions is an attractive strategy for combating cancer. Triggering p53 responses, reconstituting p53 activities through gene therapy, coercing mutant p53 to perform normal functions, manipulating p53 regulators, and activating p53 effectors are all approaches that are currently being developed. Here, we will overview 'p53-based' strategies for fighting cancer, both those under clinical trial and recent innovative concepts. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：244 / 252

页数：9

共 80 条

[1]

Abarzua P, 1996, ONCOGENE, V13, P2477

[2] Proteasome inhibition in cancer: Development of PS-341 [J].