Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma

被引：21

作者：

Lemaire, F

Millon, R

Muller, D

Rabouel, Y

Bracco, L

Abecassis, J

Wasylyk, B

机构：

[1] CNRS INSERM ULP, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[2] Ctr Paul Strauss, UPRES EA 34 30, F-67085 Strasbourg, France

[3] Exonhit Therapeut SA, F-75013 Paris, France

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 91卷 / 02期

关键词：

hypopharynx; homeodomain; development; differentiation;

D O I：

10.1038/sj.bjc.6601952

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).

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收藏

页码：258 / 261

页数：4

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