A general and efficient method for the palladium-catalyzed cross-coupling of thiols and secondary phosphines

被引：408

作者：

Murata, M ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TETRAHEDRON | 2004年 / 60卷 / 34期

关键词：

palladium catalysis; thiol cross-coupling; phosphine cross-coupling;

D O I：

10.1016/j.tet.2004.05.044

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The general and efficient cross-coupling of thiols with aryl halides was developed utilizing Pd(OAC)(2)/1,1'-bis(diisopropylphosphino)ferrocene as the catalyst. The substrate scope is broad and includes a variety of aryl bromides and chlorides, which can be coupled to aliphatic and aromatic thiols. This catalyst system has the widest substrate scope of any reported to date. The present catalyst system also enables the palladium-catalyzed coupling of secondary phosphines with aryl bromides and chlorides. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7397 / 7403

页数：7

共 45 条

[21] Highly active, air-stable palladium catalysts for the C-C and C-S bond-forming reactions of vinyl and aryl chlorides:: Use of commercially available [(t-Bu)2P(OH)]2PdCl2, [(t-Bu)2P(OH)PdCl2]2, and [[(t-Bu)2PO•••H•••OP(t-Bu)2]PdCl]2 as catalysts [J].