Neuroglian and FasciclinII can promote neurite outgrowth via the FGF receptor Heartless

被引：36

作者：

Forni, JJ ^{[1
]}

Romani, S ^{[1
]}

Doherty, P ^{[1
]}

Tear, G ^{[1
]}

机构：

[1] Kings Coll London, Mol Neurobiol Grp, MRC, Ctr Dev Neurobiol, London SE1 1UL, England

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2004年 / 26卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.mcn.2004.02.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To further investigate the role of the Drosophila cell adhesion molecules (CAMs), we have developed an in vitro assay that allows us to test the contribution individual CAMs make to promote outgrowth of specific Drosophila neurons. The extension of primary cultured neurons on a substrate of purified recombinant CAM is measured. We show that both FasciclinII and Neuroglian are able to promote outgrowth of FasciclinII or Neuroglian expressing neurons, respectively. Furthermore, this growth promotion activity is provided when the CAMs are presented both in a substrate bound or soluble form. We also show that the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR inhibitor or if Heartless function is missing from the neurons. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：282 / 291

页数：10

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