The methlonine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma

被引：35

作者：

Linnebank, M

Schmidt, S

Kölsch, H

Linnebank, A

Heun, R

Schmidt-Wolf, IGH

Glasmacher, A

Fliessbach, K

Klockgether, T

Schlegel, U

Pels, H

机构：

[1] Univ Hosp Bonn, Dept Neurol, D-53125 Bonn, Germany

[2] Univ Hosp Bonn, Dept Psychiat, D-53125 Bonn, Germany

[3] Univ Hosp Bonn, Dept Internal Med, D-53105 Bonn, Germany

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 10期

关键词：

PCNSL; methionine synthase; cystathionine beta-synthase; MTHFR; homocysteine; folate;

D O I：

10.1038/sj.bjc.6601777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI95%: 0.09-0.74; P = 0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis. (C) 2004 Cancer Research UK.

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页码：1969 / 1971

页数：3

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