Chitosan: An option for development of essential oil delivery systems for oral cavity care?

被引：112
作者：
Pedro, Andre-Sao [1 ,2 ]
Cabral-Albuquerque, Elaine [2 ]
Ferreira, Domingos [1 ]
Sarmento, Bruno [1 ,3 ]
机构：
[1] Univ Porto, Fac Pharm, Dept Pharmaceut Technol, P-4050030 Oporto, Portugal
[2] Univ Fed Bahia, Fac Pharm, Med Subject Res Lab, BR-41170290 Salvador, BA, Brazil
[3] Inst Super Ciencias Saude Norte, Dept Pharmaceut Sci, CICS, Hlth Sci Res Ctr, Gandra, Portugal
来源：
CARBOHYDRATE POLYMERS | 2009年 / 76卷 / 04期
关键词：
Buccal drug delivery systems; Chitosan; Essential oils; Microencapsulation; IN-VITRO EVALUATION; CONTROLLED-RELEASE; MUCOADHESIVE PROPERTIES; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; DRUG-DELIVERY; BUCCAL DELIVERY; VIVO EVALUATION; MICROSPHERES; FILMS;
D O I：
10.1016/j.carbpol.2008.12.016
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Microencapsulation of bioactive compounds has received increased attention in the last decade. Among the polymers used for developing microparticulated systems, chitosan has been widely cited. Obtained by deacetylation of chitin, chitosan is a natural, biodegradable, biocompatible and mucoadhesive polymer with permeability enhancement properties. These data justify its use for overcoming the reduced efficacy of conventional treatments of oral diseases. Various tests simulating the buccal environment have described controlled drug release profile and significant activity against buccal pathogens by chitosan microparticles entrapping antimicrobial agents. Considering the increasing microbial resistance to conventional antibiotics, essential oils have shown to be an important option against these pathogens. For sustained stability and prolonged release of essential oils from pharmaceutical formulations, some authors have studied the association of chitosan to them. This review disserts about the application of chitosan and essential oils on oral cavity care pointing out their association may be an interesting option. (C) 2008 Elsevier Ltd. All rights reserved.
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收藏
页码：501 / 508
页数：8
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