Brain Metastases in Non-Small-Cell Lung Cancer

被引：29

作者：

Dawe, David E. ^{[1
]}

Greenspoon, Jeffrey N. ^{[2
]}

Ellis, Peter M. ^{[2
]}

机构：

[1] Univ Manitoba, Dept Internal Med, Winnipeg, MB R3E 0V9, Canada

[2] McMaster Univ, Dept Oncol, Hamilton, ON, Canada

来源：

CLINICAL LUNG CANCER | 2014年 / 15卷 / 04期

关键词：

Chemotherapy; Radiotherapy; Review; Stereotactic radiosurgery; Targeted agents; PROPHYLACTIC CRANIAL IRRADIATION; RANDOMIZED PHASE-III; GRADED PROGNOSTIC ASSESSMENT; NERVOUS-SYSTEM PROGRESSION; PARTITIONING ANALYSIS RPA; GAMMA-KNIFE SURGERY; RADIATION-THERAPY; STEREOTACTIC RADIOSURGERY; MOTEXAFIN GADOLINIUM; SINGLE METASTASES;

D O I：

10.1016/j.cllc.2014.04.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Up to 50% of patients with advanced non-small-cell lung cancer will develop brain metastases at some point during their illness. These metastases cause a substantial burden in morbidity and mortality, which has motivated research and technological innovation over the past 2 decades. Surgery, radiotherapy, and systemic therapies have each played a role in management, with the greatest changes associated with the popularization of stereotactic radiosurgery. In this review, the evidence behind each modality used in the management of brain metastases for non small-cell lung cancer patients is examined, and recommendations regarding the current standards of care and areas of future research focus are provided. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：249 / 257

页数：9

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