High mortality rates in conservatively managed patients with acute coronary syndrome

被引:8
作者
Aune, Erlend
Hjelmesaeth, Joran
Fox, Keith A. A.
Endresen, Knut
Fox, Keith A. A.
Endresen, Knut
Otterstad, Jan Erik
机构
[1] Vestfold Hosp, Dept Cardiol, NO-3103 Tonsberg, Norway
[2] Vestfold Hosp, Dept Med, NO-3103 Tonsberg, Norway
[3] Cardiovasc Res, Edinburgh, Midlothian, Scotland
[4] Rikshosp Univ Hosp, Dept Cardiol, Oslo, Norway
关键词
acute coronary syndrome; cohort studies; coronary disease; mortality; myocardial infarction; prognosis;
D O I
10.1080/14017430600699889
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives. The revised diagnostic criteria for the acute coronary syndrome (ACS) have created the need for accurate and representative data on treatment and outcome for the three categories of ACS. Design. Consecutive patients admitted with a suspected ACS (n = 755) from February 1, 2003 to January 31, 2004 was registered and categorised into five diagnostic groups: 1) ST-elevation myocardial infarction (STEMI) (n = 126), 2) Non-ST-elevation myocardial infarction (NSTEMI) (n = 185), 3) Unstable angina pectoris (UAP) (n = 55), 4) Coronary heart disease (CHD) without ACS (n = 164) and 5) Non-coronary chest pain (n = 225). Results. All-cause one-year mortality rates were 20%, 32%, 7%, 10% and 3%, in patients with STEMI, NSTEMI, UAP, CHD without ACS and non-coronary chest pain, respectively. In patients with STEMI, 61% received immediate reperfusion therapy (ratio thrombolysis: primary PCI = 18:1). Only 3% of those with NSTEMI had PCI within two days. Conclusion. In this conservatively managed population of consecutive patients with ACS, the one-year mortality rate is significantly higher than seen in most registries and clinical trials.
引用
收藏
页码:137 / 144
页数:8
相关论文
共 21 条
[1]   Myocardial infarction redefined -: A consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction [J].
Alpert, JS ;
Antman, E ;
Apple, F ;
Armstrong, PW ;
Bassand, JP ;
de Luna, AB ;
Beller, G ;
Breithardt, G ;
Chaitman, BR ;
Clemmensen, P ;
Falk, E ;
Fishbein, MC ;
Galvani, M ;
Garson, A ;
Grines, C ;
Hamm, C ;
Hoppe, U ;
Jaffe, A ;
Katus, H ;
Kjekshus, J ;
Klein, W ;
Klootwijk, P ;
Lenfant, C ;
Levy, D ;
Levy, RI ;
Luepker, R ;
Marcus, F ;
Näslund, U ;
Ohman, M ;
Pahlm, O ;
Poole-Wilson, P ;
Popp, R ;
Pyörälä, K ;
Ravkilde, J ;
Rehnquist, N ;
Roberts, W ;
Roberts, R ;
Roelandt, J ;
Rydén, L ;
Sans, S ;
Simoons, ML ;
Thygesen, K ;
Tunstall-Pedoe, H ;
Underwood, R ;
Uretsky, BF ;
de Werf, FV ;
Voipio-Pulkki, LM ;
Wagner, G ;
Wallentin, L ;
Wijns, W .
EUROPEAN HEART JOURNAL, 2000, 21 (18) :1502-1513
[2]   INDICATIONS FOR FIBRINOLYTIC THERAPY IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION - COLLABORATIVE OVERVIEW OF EARLY MORTALITY AND MAJOR MORBIDITY RESULTS FROM ALL RANDOMIZED TRIALS OF MORE THAN 1000 PATIENTS [J].
APPLEBY, P ;
BAIGENT, C ;
COLLINS, R ;
FLATHER, M ;
PARISH, S ;
PETO, R ;
BELL, P ;
HALLS, H ;
MEAD, G ;
DIAZ, R ;
PAOLASSO, E ;
PAVIOTTI, C ;
ROMERO, G ;
CAMPBELL, T ;
OROURKE, MF ;
THOMPSON, P ;
LESAFFRE, E ;
VANDEWERF, F ;
VERSTRAETE, M ;
ARMSTRONG, PW ;
CAIRNS, JA ;
MORAN, C ;
TURPIE, AG ;
YUSUF, S ;
GRANDE, P ;
HEIKKILA, J ;
KALA, R ;
BASSAND, JP ;
BOISSEL, JP ;
BROCHIER, M ;
LEIZOROVICZ, A ;
BRUGGEMANN, T ;
KARSCH, KR ;
KASPER, W ;
LAMMERTS, D ;
NEUHAUS, KL ;
MEYER, J ;
SCHRODER, R ;
VONESSEN, R ;
SARAN, RK ;
ARDISSINO, D ;
BONADUCE, D ;
BRUNELLI, C ;
CERNIGLIARO, C ;
FORESTI, A ;
FRANZOSI, MG ;
GUIDUCCI, D ;
MAGGIONI, A ;
MAGNANI, B ;
MATTIOLI, G .
LANCET, 1994, 343 (8893) :311-322
[3]   Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [J].
Bertrand, ME ;
Simoons, ML ;
Fox, KAA ;
Wallentin, LC ;
Hamm, CW ;
McFadden, E ;
De Feyter, PJ ;
Specchia, G ;
Ruzyllo, W .
EUROPEAN HEART JOURNAL, 2002, 23 (23) :1809-1840
[4]   Outcome of ST-elevation myocardial infarction treated with thrombolysis in the unselected population is vastly different from samples of eligible patients in a large-scale, clinical trial [J].
Björklund, E ;
Lindahl, B ;
Stenestrand, U ;
Swahn, E ;
Dellborg, M ;
Pehrsson, K ;
Van De Werf, F ;
Wallentin, L .
AMERICAN HEART JOURNAL, 2004, 148 (04) :566-573
[5]   Contemporary management of acute coronary syndromes: does the practice match the evidence? The global registry of acute coronary events (GRACE) [J].
Carruthers, KF ;
Dabbous, OH ;
Flather, MD ;
Starkey, I ;
Jacob, A ;
MacLeod, D ;
Fox, KAA .
HEART, 2005, 91 (03) :290-298
[6]   European guidelines on cardiovascular disease prevention in clinical practice -: Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice [J].
De Backer, G ;
Ambrosioni, E ;
Borch-Johnsen, K ;
Brotons, C ;
Cifkova, R ;
Dallongeville, J ;
Ebrahim, S ;
Faergeman, O ;
Graham, I ;
Mancia, G ;
Cats, VM ;
Orth-Gomér, K ;
Perk, J ;
Pyörälä, K ;
Rodicio, JL ;
Sans, S ;
Sansoy, V ;
Sechtem, U ;
Silber, S ;
Thomsen, T ;
Wood, D .
EUROPEAN HEART JOURNAL, 2003, 24 (17) :1601-1610
[7]   A validated prediction model for all forms of acute coronary syndrome - Estimating the risk of 6-month postdischarge death in an international registry [J].
Eagle, KA ;
Lim, MJ ;
Dabbous, OH ;
Pieper, KS ;
Goldberg, RJ ;
Van de Werf, F ;
Goodman, SG ;
Granger, CB ;
Steg, PG ;
Gore, JM ;
Budaj, A ;
Avezum, A ;
Flather, MD ;
Fox, KAA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (22) :2727-2733
[8]   Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction:: findings from the Global Registry of Acute Coronary Events (GRACE) [J].
Eagle, KA ;
Goodman, SG ;
Avezum, A ;
Budaj, A ;
Sullivan, CM ;
López-Sendón, J .
LANCET, 2002, 359 (9304) :373-377
[9]   5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial [J].
Fox, KAA ;
Poole-Wilson, P ;
Clayton, TC ;
Henderson, RA ;
Shaw, TRD ;
Wheatley, DJ ;
Knight, R ;
Pocock, SJ .
LANCET, 2005, 366 (9489) :914-920
[10]   Management of acute coronary syndromes. Variations in practice and outcome [J].
Fox, KAA ;
Goodman, SG ;
Klein, W ;
Brieger, D ;
Steg, PG ;
Dabbous, O ;
Avezum, A .
EUROPEAN HEART JOURNAL, 2002, 23 (15) :1177-1189