Fragmentation analysis by superconducting ion detectors in matrix-assisted laser desorption/ionization (MALDI)

被引：19

作者：

Ohkubo, M ^{[1
]}

Shigeri, Y ^{[1
]}

Kinumi, T ^{[1
]}

Saito, N ^{[1
]}

Ukibe, M ^{[1
]}

Chen, YE ^{[1
]}

Kushino, A ^{[1
]}

Kurokawa, A ^{[1
]}

Sato, H ^{[1
]}

Ichimura, S ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, AIST, Tsukuba, Ibaraki 3058568, Japan

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2006年 / 559卷 / 02期

关键词：

superconducting tunnel junction; mass spectroscopy; post-source decay;

D O I：

10.1016/j.nima.2005.12.137

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Fragmentation of precursor ions of peptides or proteins is very promising for sequencing with matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (TOF-MS). Neutral fragments Lis well Lis ions produced by post-source decay (PSD) were measured by a superconducting tunnel junction detector in a linear TOF-MS. It has been demonstrated that the PSD fragments are observable as event bands with different kinetic energies at the same TOF as that of the precursor ions of polystyrene with a nominal mass of 200 kDa and bovine serum albumin of 66.43 kDa. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：779 / 781

页数：3

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