Progress in translational research on intracerebral hemorrhage: Is there an end in sight?

被引：128

作者：

Xi, Guohua ^{[1
]}

Strahle, Jennifer ^{[1
]}

Hua, Ya ^{[1
]}

Keep, Richard F. ^{[1
]}

机构：

[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

来源：

PROGRESS IN NEUROBIOLOGY | 2014年 / 115卷

基金：

美国国家卫生研究院;

关键词：

Intracerebral hemorrhage; Animal models; Brain edema; Iron; TISSUE-PLASMINOGEN-ACTIVATOR; EXTERNAL VENTRICULAR DRAINAGE; EXPERIMENTAL INTRAVENTRICULAR HEMORRHAGE; INITIAL CONSERVATIVE TREATMENT; BRAIN-BARRIER PERMEABILITY; BLOOD-PRESSURE REDUCTION; RECOMBINANT FACTOR VIIA; TUFTSIN FRAGMENT 1-3; FACTOR-KAPPA-B; EDEMA FORMATION;

D O I：

10.1016/j.pneurobio.2013.09.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracerebral hemorrhage (ICH) is a common and often fatal stroke subtype for which specific therapies and treatments remain elusive. To address this, many recent experimental and translational studies of ICH have been conducted, and these have led to several ongoing clinical trials. This review focuses on the progress of translational studies of ICH including those of the underlying causes and natural history of ICH, animal models of the condition, and effects of ICH on the immune and cardiac systems, among others. Current and potential clinical trials also are discussed for both ICH alone and with intraventricular extension. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：45 / 63

页数：19

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