Regioselective Multicomponent Sequential Synthesis of Oxa-Aza[3.3.3]propellanes

被引：16
作者：
Alizadeh, Abdolali [1 ]
Bayat, Fahimeh [1 ]
Zhu, Long-Guan [2 ]
机构：
[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2014年 / 67卷 / 06期
关键词：
POLARIZED KETENE S; S-ACETALS; CONVENIENT SYNTHESIS; CYCLIZATION; S; N-ACETALS; PROPELLANES; POT;
D O I：
10.1071/CH13654
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A concise and efficient sequential four-component approach to oxa-aza[3.3.3]propellanes has been developed by reaction of aryl isothiocyanates, malonate compounds, ninhydrin, and malononitrile in the presence of NaH in DMF. The value of this method lies in its regioselectivity, good yields, lack of a metal-catalyst, ease of handling, and creating five new bonds in one operation. No inert atmosphere or separation by column chromatography is necessary.
引用
收藏
页码：949 / 952
页数：4
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