A Simple Practical Method for the Synthesis of 4,6-Dimethoxy-1,3,5-triazin-2(1H)-one Using Dimethylamine-Functionalized Solid-Phase Reagents

被引：4

作者：

Hioki, Kazuhito ^{[1
,2
]}

Ohshima, Kelichi ^{[1
]}

Sota, Yuko ^{[1
]}

Tanaka, Miki ^{[1
]}

Kunishima, Munetaka ^{[2
,3
]}

机构：

[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Chuo Ku, Kobe, Hyogo 6508586, Japan

[2] Kobe Gakuin Univ, Cooperat Res Ctr Life Sci, Chuo Ku, Kobe, Hyogo 6508586, Japan

[3] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Kanazawa, Ishikawa 9201192, Japan

来源：

SYNTHESIS-STUTTGART | 2009年 / 04期

关键词：

heterocycles; amines; supported reagents; nucleophilic aromatic substitutions; alcoholysis; CONDENSING AGENT; CARBOXYLIC-ACIDS; REACTIVE DYES; DMT-MM; AMIDES; AMINES;

D O I：

10.1055/s-0028-1083330

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple practical method for the synthesis of 4,6-dimethoxy-1,3,5 triazin-2(IH)-one was developed. The desired product was easily obtained from 2-chloro-4,6-dimethoxy-1,3,5-triazine and acetic acid by shaking with dimethylamine-functionalized silica gel in ethanol. It was also demonstrated that the silica gel could be recycled by washing it with diluted aqueous ammonia solution.

引用

页码：542 / 544

页数：3

共 4 条

[1] Synthesis of Non-natural Xyloglucans by Polycondensation of 4,6-Dimethoxy-1,3,5-triazin-2-yl Oligosaccharide Monomers Catalyzed by Endo-β-1,4-glucanase
Tanaka, Tomonari
Noguchi, Masato
Ishihara, Masaki
Kobayashi, Atsushi
Shoda, Shin-ichiro
POLYMERS AND ORGANIC CHEMISTRY, 2010, 297 : 200 - 209
[2] An Easy and Convenient Synthesis of β-Lactams via a One-Pot Staudinger Reaction with 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride Starting from Substituted Carboxylic Acids
Zarei, Maaroof
LETTERS IN ORGANIC CHEMISTRY, 2015, 12 (01) : 44 - 49
[3] Practical One-Pot Synthesis of 4,6-Bis(hetero)aryl- and 4-(Hetero) aryl-6-methyl-substituted 1,3,5-Triazin-2-amines
Calheiros, Lais C.
Moura, Sidnei
Back, Davi F. F.
Paveglio, Guilherme C. C.
Casagrande, Gleison A. A.
Pizzuti, Lucas
SYNTHESIS-STUTTGART, 2023, 55 (07): : 1130 - 1138
[4] Solid-phase synthesis of 4H-2-(3-hydroxy-4-methoxyphenyl)naphtho[1,2-b]pyran-1-one
Cironi, P
Albericio, F
Alvarez, M
TETRAHEDRON LETTERS, 2004, 45 (39) : 7311 - 7314

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