Effect of 6-Month Therapy With Perindopril A on Structural-Functional State of Arterial Vascular Bed in Patients With Chronic Heart Failure

In patients with chronic heart failure (CHF) endothelial dysfunction of large vessels is an independent predictor of repeated hospitalizations because of CHF aggravation and cardiac death. Objective. To evaluate the effect of perindopril A (5-10 mg/day) on endothelial function of large vessels in patients with CHF. Material and methods. The study included 30 patients with NYHA class II-III CHF aged 45-70 years. Patients took perindopril A 5-10 mg for 6 months. Patients underwent 24-h BP monitoring, assessment of endothelium vasodilation. Results. In the end of period of treatment hypotensive effect and improvement of endothelial function of large vessels were achieved. We observed increase of flow-mediated vasodilation (FMD) measured by high-frequency ultrasound of brachial artery after reactive hyperemia: FMD1 4.25 (3.9; 4.8) vs FMD2 6.8 (5.1; 7.4), p = 0.003) and enhancement of pulse wave amplitude estimated by photoplethysmography (shear phase SF): SF1 6.62 (2.4; 8.7) vs SF2 7.36 (3.8; 10.2) (p = 0.003).