The one year exercise and lifestyle intervention program KLAKS: Effects on anthropometric parameters, cardiometabolic risk factors and glycemic control in childhood obesity.

被引：25

作者：

Blueher, Susann ^{[1
]}

Petroff, David ^{[1
,2
]}

Wagner, Antje ^{[3
]}

Warich, Katja ^{[3
]}

Gausche, Ruth ^{[4
]}

Klemm, Thorsten ^{[5
]}

Wagner, Mario ^{[6
]}

Keller, Alexandra ^{[4
,7
]}

机构：

[1] Univ Leipzig, IFB Adipos Dis, Med Ctr, D-04103 Leipzig, Germany

[2] Univ Leipzig, Ctr Clin Studies, D-04107 Leipzig, Germany

[3] KLAKS eV, D-04109 Leipzig, Germany

[4] Univ Leipzig, CrescNet gGmbH, D-04103 Leipzig, Germany

[5] MVZ Lab Dr Reising Ackermann & Colleagues, D-04289 Leipzig, Germany

[6] Gesundheitssportverein Leipzig eV, D-04109 Leipzig, Germany

[7] Pediat Med Ctr, D-04103 Leipzig, Germany

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2014年 / 63卷 / 03期

关键词：

Obesity therapy; KLAKS program; Childhood obesity; Metabolic syndrome; Oral glucose tolerance test; BODY-MASS INDEX; METABOLIC SYNDROME; RESISTANCE EXERCISE; CARDIOVASCULAR RISK; YOUNG-ADULTS; CHILDREN; OVERWEIGHT; ADOLESCENTS; RESTRICTION; SENSITIVITY;

D O I：

10.1016/j.metabol.2013.11.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Regular physical exercise within structured lifestyle programs may improve weight status and minimize metabolic risk factors in childhood obesity. The aim of this study was to evaluate the effect of the one-year combined physical exercise/lifestyle program KLAKS on anthropometric and metabolic parameters and glycemic control in childhood obesity. Materials and Methods. 142 overweight/obese (BMI > 90th percentile) candidates (7-18 years) were enrolled, 115 participants completed the program. Anthropometrics and biochemical parameters were obtained at beginning and completion. An oral glucose tolerance test (OGTT) was performed in a subgroup of participants. Course of glucose and insulin levels within OGTT was correlated with several parameters and is reported here for those who completed the program. Results. The mean standard deviation scores (SDS) decreased significantly for BMI, waist circumference, waist-to-height ratio (WHtR) and percentage body fat (all p < 0.01). Improved metabolic risk markers included mean glucose levels within an OGTT at follow-up compared to baseline (p < 0.0001) and HbA1c (p = 0.05) as well as indications of improvement for gamma-glutamyl-transferase and free fatty acids. Conclusions. The one-year combined exercise/lifestyle program KLAKS significantly improves markers of obesity and glycemic control. Impaired cardiometabolic risk markers, even subclinical, are also favorably influenced by program participation. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：422 / 430

页数：9

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