Enhanced lipid peroxidation and inflammation during heat exposure in rats of different ages: Role of α-tocopherol

To investigate early events possibly related to the development of heat shock, we examined whether inflammatory-(interleukin-6, tumor necrosis factor alpha and 15-keto-13,14-dihydro-PGF(2 alpha)) and peroxidative-(8-iso-PGF(2 alpha) and malondialdehyde) markers are altered during acute heat exposure and aging. We also studied the relationships between inflammatory and peroxidative markers in these settings. In order to prevent these reactions developed as a consequence of the conditions mentioned above, we tested the effects of alpha-tocopherol. Our results demonstrated that 15-keto-13,14-dihydro-PGF2(alpha) and malondialdehyde in the liver were altered during acute heat exposure in The young and middle-aged rats and could be predicted by changes in the levels of circulatory cytokines. Regardless of age, the supplementation with alpha-tocopherol prevented changes in the plasma cytokine levels and 15-keto-13,14-dihydro-PGF(2 alpha) and malondialdehyde levels in the liver, during acute heat exposure. This study notably emphasized the ability of a-tocopherol to prevent different heat induced mechanisms, involved in induction of inflammatory or peroxidative reactions. (C) 2013 Elsevier Ltd. All rights reserved.