Premorbid adjustment and neuropsychological performance in schizophrenia

被引:48
作者
Silverstein, ML
Mavrolefteros, G
Close, D
机构
[1] Long Isl Univ, Dept Psychol, Brookville, NY USA
[2] N Cent Bronx Hosp, Dept Psychiat, Bronx, NY USA
[3] Pilgrim Psychiat Ctr, Brentwood, NY USA
关键词
neuropsychology; social functioning; premorbid adjustment;
D O I
10.1093/oxfordjournals.schbul.a006918
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
To examine the relationship between premorbid adjustment and neuropsychological deficit in schizophrenia, this report examined retrospective ratings of social and school adjustment during three age epochs (childhood, early adolescence, and late adolescence) as predictors of neurocognitive performance in 61 clinically and pharmacologically stabilized schizophrenia outpatients. Results indicated greater cognitive deficits when premorbid adjustment was unfavorable, particularly for measures of attention and executive functions. Premorbid number and quality of peer relationships and psychosocial adaptation to the school environment were more closely related to neuropsychological performance during adulthood than were premorbid withdrawal and premorbid academic performance. Early onset of poor premorbid adjustment rather than deterioration from childhood to adolescence was associated with greater neuropsychological disturbance in adulthood. It is suggested that childhood onset of premorbid deficits in selective areas of social and academic adjustment appears to influence the cognitive performance seen in adult schizophrenia. This study is consistent with findings from other related reports; it extends these findings to a larger and clinically stabilized sample.
引用
收藏
页码:157 / 165
页数:9
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