Switching on cilia: transcriptional networks regulating ciliogenesis

被引：250
作者：
Choksi, Semil P. [1 ]
Lauter, Gilbert [2 ]
Swoboda, Peter [2 ]
Roy, Sudipto [1 ,3 ]
机构：
[1] Inst Mol & Cell Biol, Singapore 138673, Singapore
[2] Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden
[3] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
来源：
DEVELOPMENT | 2014年 / 141卷 / 07期
基金：
瑞典研究理事会;
关键词：
Cilia; Ciliogenesis; FOXJ1; Motile cilia; RFX; Transcriptional regulation; LEFT-RIGHT ASYMMETRY; SCANNING-ELECTRON-MICROSCOPY; BARE LYMPHOCYTE SYNDROME; DNA-BINDING PROTEINS; DRIVEN FLUID-FLOW; CAENORHABDITIS-ELEGANS; C-ELEGANS; INTRAFLAGELLAR TRANSPORT; RFX FAMILY; EPITHELIAL-CELLS;
D O I：
10.1242/dev.074666
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.
引用
收藏
页码：1427 / 1441
页数：15
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