Calothrixins A and B, novel pentacyclic metabolites from Calothrix cyanobacteria with potent activity against malaria parasites and human cancer cells

被引：203
作者：
Rickards, RW [1 ]
Rothschild, JM
Willis, AC
de Chazal, NM
Kirk, J
Kirk, K
Saliba, KJ
Smith, GD
机构：
[1] Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia
[2] Australian Natl Univ, Fac Sci, Div Biochem & Mol Biol, Canberra, ACT 0200, Australia
来源：
TETRAHEDRON | 1999年 / 55卷 / 47期
关键词：
anticancer; antiplasmodial; cyanobacteria; polycyclic heterocyclic compounds;
D O I：
10.1016/S0040-4020(99)00833-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cell extracts from photoautrophic cultures of two cyanobacterial Calothrix isolates inhibited the growth in vitro of a chloroquine-resistant strain of the malaria parasite, Plasmodium falciparum, and of human HeLa cancer cells, in a dose-dependent manner. Bioassay;directed fractionation of the extracts led to the isolation and structural characterization of calothrixins A (1) and B (2), pentacyclic metabolites with an indolo[3,2-j]phenanthridine ring system unique amongst natural products, which exert their growth-inhibitory effects at nanomolar concentrations. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：13513 / 13520
页数：8
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