Bio-compatibility of ion beam-modified and RGD-grafted polyethylene

被引：43

作者：

Rocková-Hlavácková, K

Svorcík, V

Bacáková, L

Dvoránková, B

Heitz, J

Hnatowicz, V

机构：

[1] Inst Chem Technol, Dept Solid State Engn, CR-16628 Prague, Czech Republic

[2] Acad Sci Czech Republ, Inst Physiol, Prague 14202, Czech Republic

[3] Charles Univ Prague, Fac Med 3, Prague Burn Ctr, Prague 10034, Czech Republic

[4] Johannes Kepler Univ Linz, A-4040 Linz, Austria

[5] Acad Sci Czech Republ, Inst Phys Nucl, CZ-25068 Rez, Czech Republic

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2004年 / 225卷 / 03期

关键词：

modified polyethylene; ion beam; RGD grafting; chemical structure; interaction of fibroblasts;

D O I：

10.1016/j.nimb.2004.05.004

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Polyethylene (PE) was implanted with 15 keV Ar+ and Kr+ ions to the fluences from 3 x 10(12)-1 x 10(15) cm(-2) and subsequently grafted with amino acid sequence Arg-Gly-Asp (RGD), i.e. a minimum adhesion motif recognized by integrin receptors on cells. The structural changes of PE were studied using goniometric technique, UV-VIS, LIF spectroscopy and by measuring specimen electrical resistance. The adhesion and proliferation of mouse embryonic fibroblasts 3T3 on the modified PE were studied under in vitro conditions. Addition of RGD sequence onto double bonds created by the ion irradiation on polymeric chain was observed. The adhesion and proliferation of the 3T3 cells is increased by ion implantation and additionally also by RGD grafting. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：275 / 282

页数：8

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