Organ Preservation after Endoscopic Resection of Early Esophageal Cancer with a High Risk of Lymph Node Involvement

Simple Summary Virtually all early (T1) esophageal cancers can be resected endoscopically. However, the presence of histologic criteria on the resection specimen (deep submucosal invasion, lymphovascular involvement, poor tumor differentiation) are believed to be associated with a high risk (> 10%) of lymph node involvement. Therefore, the presence of such histoprognostic criteria currently require an esophagectomy. However, some patients are unfit for surgery or decline surgery, and undergo close follow-up or chemoradiotherapy. We analyzed the outcomes of these patients. We included 41 patients, of which thirteen (32%) were closely monitored, and 28 (68%) were treated by chemoradiotherapy or radiotherapy alone. After a mean follow-up of 19 and 28 months, cancer specific survival was 100% and 96%, respectively. Our study shows that close follow-up may be an alternative to esophagectomy after endoscopic resection of an early esophageal cancer with a predicted high risk of lymph node involvement. Background: Esophagectomy is recommended after endoscopic resection of an early esophageal cancer when pejorative histoprognostic criteria indicate a high risk of lymph node involvement. Our aim was to analyze the clinical outcomes of a non-surgical, organ preserving management in this clinical setting. Patients and Methods: This retrospective study was performed in two tertiary centers from 2015 to 2020. Patients were included if they had histologically complete resection of an early esophageal cancer, with poor differentiation, lymphovascular invasion or deep submucosal invasion. Endoscopic resection was followed by chemoradiotherapy or follow-up in case of surgical contraindications or patient refusal. Outcome measures were disease-free survival (DFS), overall survival (OS), cancer specific survival (CSS) and toxicity of chemoradiotherapy. Results: Forty-one patients (36 with squamous cell carcinoma and 5 with adenocarcinomas) were included. The estimated high risk of lymph node involvement was based on poor differentiation (10/41; 24%), lympho-vascular invasion (11/41; 27%), muscularis mucosa invasion or deep sub-mucosal invasion (38/41; 93%). Thirteen patients (13/41; 32%) were closely monitored, and 28 (28/41; 68%) were treated by chemoradiotherapy or radiotherapy alone. In the close follow-up group, DFS, OS and CSS were 92%, 92% and 100%, respectively vs. 75%, 79% and 96%, respectively in the chemoradiotherapy group at the end of the follow-up. Serious adverse events related to chemoradiotherapy occurred in 10% of the patients. There were no treatment-related deaths. Conclusions: Our study shows that close follow-up may be an alternative to systematic esophagectomy after endoscopic resection of early esophageal cancer with a predicted high risk of lymph node involvement.