Brain MRI findings with vigabatrin therapy: case report and literature review

被引：6

作者：

Hussain, Kaiser ^{[1
,2
]}

Walsh, Thomas J. ^{[2
]}

Chazen, J. Levi ^{[1
]}

机构：

[1] Cornell Univ, Weill Cornell Med Coll, Dept Radiol, New York, NY 10065 USA

[2] Cornell Univ, Weill Cornell Med Coll, Div Transplantat Oncol & Infect Dis, New York, NY 10065 USA

来源：

CLINICAL IMAGING | 2016年 / 40卷 / 01期

关键词：

Vigabatrin; Epilepsy; Infantile spasm; Brain MRI; INDUCED INTRAMYELINIC EDEMA; INFANTILE SPASMS; INDUCED LESIONS; WEST-SYNDROME; ABNORMALITIES;

D O I：

10.1016/j.clinimag.2015.07.016

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Infantile spasm or West syndrome is a pediatric epileptic disorder characterized by flexor and/or extensor spasms beginning in childhood. Vigabatrin is an effective medical therapy for infantile spasm but has pronounced, potentially worrisome imaging findings in patients receiving therapy. We present the case of an 8-month-old infant with such brain magnetic resonance imaging findings after treatment initiation. In this article, we highlight the imaging changes and discuss the differential diagnosis along with the required follow-up. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：180 / 182

页数：3

共 26 条

[1] NEUROPATHOLOGY OF A HUMAN HIPPOCAMPUS FOLLOWING LONG-TERM TREATMENT WITH VIGABATRIN - LACK OF MICROVACUOLES [J].

AGOSTI, R ;

YASARGIL, G ;

EGLI, M ;

WIESER, HG ;

WIESTLER, OD .

EPILEPSY RESEARCH, 1990, 6 (02) :166-170

[2] A STUDY OF THE EFFECTS OF VIGABATRIN ON THE CENTRAL-NERVOUS-SYSTEM AND RETINA OF SPRAGUE DAWLEY AND LISTER-HOODED RATS [J].

BUTLER, WH ;

FORD, GP ;

NEWBERNE, JW .

TOXICOLOGIC PATHOLOGY, 1987, 15 (02) :143-148

[3] Etiologic classification of infantile spasms in 140 cases: Role of positron emission tomography [J].

Chugani, HT ;

Conti, JR .

JOURNAL OF CHILD NEUROLOGY, 1996, 11 (01) :44-48

[4]

Cocito L, 1992, Seizure, V1, P163, DOI 10.1016/1059-1311(92)90019-W

[5] The potential for vigabatrin-induced intramyelinic edema in humans [J].

Cohen, JA ;

Fisher, RS ;

Brigell, MG ;

Peyster, RG ;

Sze, G .

EPILEPSIA, 2000, 41 (02) :148-157

[6] Transient magnetic resonance diffusion abnormalities in West syndrome: the radiological expression of non-convulsive status epilepticus? [J].

Desguerre, Isabelle ;

Marti, Ixtasu ;

Valayannopoulos, Vassili ;

Bahi-Buisson, Nadia ;

Dulac, Olivier ;

Plouin, Perrine ;

DeLonlay, Pascale ;

Hertz-Pannier, Lucie ;

Boddaert, Nathalie .

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2008, 50 (02) :112-116

[7] Vigabatrin-associated reversible MRI signal changes in patients with infantile spasms [J].

Dracopoulos, Aphrodite ;

Widjaja, Elysa ;

Raybaud, Charles ;

Westall, Carol A. ;

Snead, O. Carter, III .

EPILEPSIA, 2010, 51 (07) :1297-1304

[8]

DREIFUSS F, 1992, EPILEPSIA, V33, P195

[9] CHRONIC TOXICITY STUDIES WITH VIGABATRIN, A GABA-TRANSAMINASE INHIBITOR [J].

GIBSON, JP ;

YARRINGTON, JT ;

LOUDY, DE ;

GERBIG, CG ;

HURST, GH ;

NEWBERNE, JW .

TOXICOLOGIC PATHOLOGY, 1990, 18 (02) :225-238

[10] Evidence-based guideline update: Medical treatment of infantile spasms Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society [J].

Go, C. Y. ;

Mackay, M. T. ;

Weiss, S. K. ;

Stephens, D. ;

Adams-Webber, T. ;

Ashwal, S. ;

Snead, O. C., III .

NEUROLOGY, 2012, 78 (24) :1974-1980

← 1 2 3 →