PHENOLIC CONSTITUENTS WITH THEIR α-GLUCOSIDASE INHIBITORY ACTIVITIES FROM THE LEAVES OF Viburnum melanocarpum

被引：2

作者：

Tang, Yi-Yuan ^{[1
]}

Zhao, Zi-Yang ^{[1
]}

Chen, Jia ^{[1
]}

Zhao, Chun-Chao ^{[1
]}

Shao, Jian-Hua ^{[1
]}

机构：

[1] Yangzhou Univ, Jiangsu Key Lab Crop Genet & Physiol, Coinnovat Ctr Modern Prod Technol Grain Crops, Yangzhou 225009, Jiangsu, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2021年 / 57卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Adoxaceae; Viburnum melanocarpum; natural compounds; alpha-glucosidase inhibition;

D O I：

10.1007/s10600-021-03281-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new compound 1, together with two known compounds (2, 3), has been isolated from the ethanolic extract of Viburnum melanocarpum leaves. Their structures were elucidated by extensive spectroscopic evidence and chemical method. In the in vitro assay, compounds 1 and 3 displayed potent inhibitory activity against alpha-glucosidase with IC50 values of 6.28 mu M and 12.73 mu M, respectively.

引用

页码：56 / 58

页数：3

共 9 条

[1] A NEW ALLOSIDE FROM Neocheiropteris palmatopedata [J].

Chen, Ye-Gao ;

Yang, Jian-Hong ;

Zhang, Yan ;

Liu, Ying .

CHEMISTRY OF NATURAL COMPOUNDS, 2010, 46 (02) :173-175

[2] Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots [J].

Kanho, H ;

Yaoya, S ;

Kawahara, N ;

Nakane, T ;

Takase, Y ;

Masuda, K ;

Kuroyanagi, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (04) :361-365

[3] SYNTHESIS AND CHARACTERIZATION OF THE NATURALLY-OCCURRING MONOCYCLIC GAMMA-PYRONE GLUCOSIDES [J].

LOOKER, JH ;

FISHER, MS .

JOURNAL OF CARBOHYDRATE CHEMISTRY, 1985, 4 (03) :381-392

[4]

Ozola Liene, 2018, Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences, V72, P97, DOI 10.2478/prolas-2018-0016

[5] Two New Phenolic Glycosides from Viburnum melanocarpum [J].

Shen, Jie ;

Shao, Jian-Hua ;

Chen, Jia ;

Liu, Wen-Yan ;

Zhao, Chun-Chao .

CHEMISTRY OF NATURAL COMPOUNDS, 2019, 55 (01) :25-27

[6] 天然阿洛糖苷的研究进展 [J].

王莹莹 ;

田雷瑜 ;

杨燕 ;

孙稚颖 ;

王伟 .

药学学报, 2017, (03) :378-389

[7] Phenolic glycoside constituents from Brassica rapa flowers and their ?-glucosidase inhibitory activity [J].

Zhao, Chun-Chao ;

Shen, Jie ;

Chen, Jia ;

Shao, Jian-Hua ;

Li, Ke-Huan ;

Gu, Wen-Yan ;

Miao, Ben-Jie .

NATURAL PRODUCT RESEARCH, 2019, 33 (23) :3398-3403

[8] Lignan glycosides from the stems of Viburnum melanocarpum and their α-glucosidase inhibitory activity [J].

Zhao, Chunchao ;

Chen, Jia ;

Shao, Jianhua ;

Shen, Jie ;

Gu, Wenyan ;

Zhang, Xiaohui ;

Sha, Yusi .

HOLZFORSCHUNG, 2020, 74 (01) :88-93

[9] Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity [J].

Zhao, Chunchao ;

Chen, Jia ;

Shao, Jianhua ;

Shen, Jie ;

Xu, Xiaoqing ;

Li, Kehuan ;

Gu, Wenyan ;

Zhao, Min ;

Fan, Judi .

HOLZFORSCHUNG, 2018, 72 (12) :1017-1024

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