Extended Peptide Nucleic Acid Nucleobases Based on Isoorotic Acid for the Recognition of A-U Base Pairs in Double-Stranded RNA

被引：7

作者：

Brodyagin, Nikita ^{[2
]}

Maryniak, Aubrey L. ^{[1
]}

Kumpina, Ilze ^{[3
]}

Talbott, John M. ^{[1
]}

Katkevics, Martins ^{[3
]}

Rozners, Eriks ^{[2
]}

MacKay, James A. ^{[1
]}

机构：

[1] Elizabethtown Coll, Dept Chem & Biochem, Elizabethtown, PA 17022 USA

[2] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA

[3] Latvian Inst Organ Synth, Aizkraukles 21, LV-1006 Riga, Latvia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 13期

基金：

美国国家科学基金会;

关键词：

nucleic acids; nucleobases; peptide nucleic acids; RNA recognition; triple helix; SEQUENCE-SELECTIVE RECOGNITION; THYMINE; PNA;

D O I：

10.1002/chem.202005401

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptide nucleic acids (PNA) with extended isoorotamide containing nucleobases (I-o) were designed for binding A-U base pairs in double-stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments revealed improved affinity for A-U using the Io scaffold in PNA. PNAs having four sequential Io extended nucleobases maintained high binding affinity.

引用

页码：4332 / 4335

页数：4

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