Organometallic iron: the key to biological hydrogen metabolism

被引：100
作者：
Adams, MWW [1 ]
Stiefel, EI
机构：
[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
[2] ExxonMobil Res & Engn Co, Corp Strateg Res, Annandale, NJ 08801 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 02期
关键词：
D O I：
10.1016/S1367-5931(99)00077-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
X-ray crystallography of iron-hydrogenases reveals that the active-site H-cluster contains an unmistakably organometallic dinuclear iron subcluster. The nickel-hydrogenases, which in general play different metabolic roles, have a distinct but related active-site structure. The new structural definition, combined with chemical analogs and theoretical treatment, points toward mechanistic understanding of iron-hydrogenases and the possibility of a unified mechanism for all hydrogenases.
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收藏
页码：214 / 220
页数：7
相关论文
共 71 条
  • [1] ADAMS MWW, 1984, J BIOL CHEM, V259, P7045
  • [2] Biochemistry - Biological hydrogen production: Not so elementary
    Adams, MWW
    Stiefel, EI
    [J]. SCIENCE, 1998, 282 (5395) : 1842 - 1843
  • [3] HYDROGENASE
    ADAMS, MWW
    MORTENSON, LE
    CHEN, JS
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 594 (2-3) : 105 - 176
  • [4] THE STRUCTURE AND MECHANISM OF IRON-HYDROGENASES
    ADAMS, MWW
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1020 (02) : 115 - 145
  • [5] THE PURIFICATION OF HYDROGENASE-II (UPTAKE HYDROGENASE) FROM THE ANAEROBIC N-2-FIXING BACTERIUM CLOSTRIDIUM-PASTEURIANUM
    ADAMS, MWW
    MORTENSON, LE
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 766 (01) : 51 - 61
  • [6] A hydrogenosome with a genome
    Akhmanova, A
    Voncken, F
    van Alen, T
    van Hoek, A
    Boxma, B
    Vogels, G
    Veenhuiss, M
    Hackstein, JHP
    [J]. NATURE, 1998, 396 (6711) : 527 - 528
  • [7] NICKEL HYDROGENASES - IN SEARCH OF THE ACTIVE-SITE
    ALBRACHT, SPJ
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1994, 1188 (03): : 167 - 204
  • [8] A hybrid density functional theory molecular mechanics study of nickel-iron hydrogenase: Investigation of the active site redox states
    Amara, P
    Volbeda, A
    Fontecilla-Camps, JC
    Field, MJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (18) : 4468 - 4477
  • [9] INFRARED-DETECTABLE GROUPS SENSE CHANGES IN CHARGE-DENSITY ON THE NICKEL CENTER IN HYDROGENASE FROM CHROMATIUM-VINOSUM
    BAGLEY, KA
    DUIN, EC
    ROSEBOOM, W
    ALBRACHT, SPJ
    WOODRUFF, WH
    [J]. BIOCHEMISTRY, 1995, 34 (16) : 5527 - 5535
  • [10] Identification and characterization of [Fe]-hydrogenases in the hydrogenosome of Trichomonas vaginalis
    Bui, ETN
    Johnson, PJ
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1996, 76 (1-2) : 305 - 310
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