Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome

被引：21
作者：
de Vega, Wilfred C. [1 ,2 ]
Erdman, Lauren [3 ,4 ]
Vernon, Suzanne D. [5 ]
Goldenberg, Anna [3 ,4 ]
McGowan, Patrick O. [1 ,2 ,6 ,7 ]
机构：
[1] Univ Toronto, Dept Biol Sci, Toronto, ON, Canada
[2] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada
[3] Univ Toronto, Dept Comp Sci, Toronto, ON, Canada
[4] SickKids Res Inst, Genet & Genome Biol, Toronto, ON, Canada
[5] Bateman Horne Ctr Excellence, Salt Lake City, UT 84102 USA
[6] Univ Toronto, Dept Psychol, Toronto, ON, Canada
[7] Univ Toronto, Fac Med, Dept Physiol, Toronto, ON, Canada
来源：
EPIGENOMICS | 2018年 / 10卷 / 05期
关键词：
CFS; chronic fatigue syndrome; clinical subtyping; complex disease; DNA methylation; epigenetics; health survey; myalgic encephalomyelitis; similarity network fusion; symptom heterogeneity; CHRONIC UNEXPLAINED FATIGUE; GENE-EXPRESSION SUBTYPES; EMPIRICAL DELINEATION; MULTIPLE-SCLEROSIS; SYNDROME ME/CFS; NETWORK; GENOME; MICROARRAY; BRAIN; HETEROGENEITY;
D O I：
10.2217/epi-2017-0150
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) based on DNA methylation profiles and health scores. Methods: DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes. Results: We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes. Conclusion: ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
引用
收藏
页码：539 / 557
页数：19
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