Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome

被引：22

作者：

de Vega, Wilfred C. ^{[1
,2
]}

Erdman, Lauren ^{[3
,4
]}

Vernon, Suzanne D. ^{[5
]}

Goldenberg, Anna ^{[3
,4
]}

McGowan, Patrick O. ^{[1
,2
,6
,7
]}

机构：

[1] Univ Toronto, Dept Biol Sci, Toronto, ON, Canada

[2] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada

[3] Univ Toronto, Dept Comp Sci, Toronto, ON, Canada

[4] SickKids Res Inst, Genet & Genome Biol, Toronto, ON, Canada

[5] Bateman Horne Ctr Excellence, Salt Lake City, UT 84102 USA

[6] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[7] Univ Toronto, Fac Med, Dept Physiol, Toronto, ON, Canada

来源：

EPIGENOMICS | 2018年 / 10卷 / 05期

关键词：

CFS; chronic fatigue syndrome; clinical subtyping; complex disease; DNA methylation; epigenetics; health survey; myalgic encephalomyelitis; similarity network fusion; symptom heterogeneity; CHRONIC UNEXPLAINED FATIGUE; GENE-EXPRESSION SUBTYPES; EMPIRICAL DELINEATION; MULTIPLE-SCLEROSIS; SYNDROME ME/CFS; NETWORK; GENOME; MICROARRAY; BRAIN; HETEROGENEITY;

D O I：

10.2217/epi-2017-0150

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) based on DNA methylation profiles and health scores. Methods: DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes. Results: We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes. Conclusion: ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.

引用

页码：539 / 557

页数：19

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