Cost-effectiveness analysis of human papillomavirus-vaccination programs to prevent cervical cancer in Austria

被引：51

作者：

Zechmeister, Ingrid ^{[1
]}

de Blasio, Birgitte Freiesleben ^{[2
]}

Garnett, Geoff ^{[3
]}

Neilson, Aileen Rae ^{[4
]}

Siebert, Uwe ^{[5
,6
,7
,8
]}

机构：

[1] Ludwig Boltzmann Inst Hlth Technol Assessment, A-1090 Vienna, Austria

[2] Univ Oslo, Inst Basic Med Sci, Oslo, Norway

[3] Univ London Imperial Coll Sci Technol & Med, Inst Microparasite Epidemiol, London, England

[4] Norwegian Knowledge Ctr Hlth Serv, Oslo, Norway

[5] Univ Hlth Sci Med Informat & Technol, Dept Publ Hlth Med Decis Making & HTA, Hall In Tirol, LT, Austria

[6] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Ctr Decis Sci, Boston, MA 02115 USA

[7] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Inst Technol Assessment, Boston, MA USA

[8] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiol, Boston, MA USA

来源：

VACCINE | 2009年 / 27卷 / 37期

关键词：

HPV-vaccination; Cost-effectiveness; Cervical cancer screening; ECONOMIC-EVALUATION; HPV VACCINATION; NATURAL-HISTORY; MODEL; TRANSFERABILITY; INFECTION; HEALTH; IMPACT; WOMEN;

D O I：

10.1016/j.vaccine.2009.06.039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: The study predicts long-term cervical cancer related population health and economic effects of introducing the HPV-vaccination for 12-year-old girls (and boys) in addition to current screening compared with screening only. Method: Health effects are predicted by a dynamic transmission model. Model results are used to calculate incremental cost-effectiveness ratios (ICER) in (sic) per life year gained (LYG) for a time-horizon between 2008 and 2060 from a public payer and a societal perspective. Results: Vaccination of girls results a discounted ICER of (sic) 64,000/LYG and (sic) 50,000/LYG from a payer's and societal perspectives respectively. The additional vaccination of boys increases the ICER to (sic) 311,000 and (sic) 299,000/LYG respectively. Results were most sensitive to vaccination price, discount rate and time-horizon. Conclusion: HPV-vaccination for girls should be cost-effective when adopting a longer time-horizon and a societal perspective. Applying a shorter time frame and a payer's perspective or vaccinating boys may not be cost-effective without reducing the vaccine price. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5133 / 5141

页数：9

共 45 条

[1]

[Anonymous], 1996, Cost-effectiveness in health and medicine

[2]

[Anonymous], 2003, EUR J HLTH EC, DOI DOI 10.1007/S10198-003-0205-2

[3] Cost-effectiveness analysis of the introduction of a quadrivalent human papillomavirus vaccine in France [J].

Bergeron, Christine ;

Largeron, Nathalie ;

McAllister, Ruth ;

Mathevet, Patrice ;

Remy, Vanessa .

INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE, 2008, 24 (01) :10-19

[4] The potential cost-effectiveness of prophylactic human papillomavirus vaccines in Canada [J].

Brisson, Marc ;

Van de Velde, Nicolas ;

De Wals, Philippe ;

Boily, Marie-Claude .

VACCINE, 2007, 25 (29) :5399-5408

[5]

*BUND GES FAM JUG, 2007, LKF STAT EINZ

[6] Cross sectional study of conventional cervical smear, monolayer cytology, and human papillomavirus DNA testing for cervical cancer screening [J].

Coste, J ;

Cochand-Priollet, A ;

de Cremoux, P ;

Le Galès, C ;

Cartier, I ;

Molinié, V ;

Labbé, S ;

Vacher-Lavenu, MC ;

Vielh, P .

BMJ-BRITISH MEDICAL JOURNAL, 2003, 326 (7392) :733-736A

[7]

Doren M, 2008, WISSENSCHAFTLER INNE, V25, P11

[8]

Drummond MF, 2005, Methods for The Economic Evaluation of Health Care Programmes

[9] Transferability of Economic Evaluations Across Jurisdictions: ISPOR Good Research Practices Task Force Report [J].

Drummond, Michael ;

Barbieri, Marco ;

Cook, John ;

Glick, Henry A. ;

Lis, Joanna ;

Malik, Farzana ;

Reed, Shelby D. ;

Rutten, Frans ;

Sculpher, Mark ;

Severens, Johan .

VALUE IN HEALTH, 2009, 12 (04) :409-418

[10] Model for assessing human papillomavirus vaccination strategies [J].

Elbasha, Elamin H. ;

Dasbach, Erik J. ;

Insinga, Ralph P. .

EMERGING INFECTIOUS DISEASES, 2007, 13 (01) :28-41

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