Association Between Autophagy and Neurodegenerative Diseases

被引：153

作者：

Fujikake, Nobuhiro ^{[1
]}

Shin, Minkyoung ^{[1
]}

Shimizu, Shigeomi ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Med Res Inst, Dept Pathol Cell Biol, Tokyo, Japan

来源：

FRONTIERS IN NEUROSCIENCE | 2018年 / 12卷

关键词：

autophagy; neurodegenerative disease; Alzheimer disease; tauopathy; Parkinson disease; amyotrophic lateral sclerosis; polyglutamine disease; AMYOTROPHIC-LATERAL-SCLEROSIS; TRANSGENIC MOUSE MODEL; TAUOPATHY IN-VITRO; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; HUNTINGTON-DISEASE; POLYGLUTAMINE EXPANSIONS; DAMAGED MITOCHONDRIA; SELECTIVE AUTOPHAGY;

D O I：

10.3389/fnins.2018.00255

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autophagy is a phylogenetically conserved mechanism that controls the degradation of subcellular constituents, including misfolded proteins, and damaged organelles. The progression of many neurodegenerative diseases is thought to be driven by the aggregation of misfolded proteins; therefore, autophagic activity is thought to affect disease severity to some extent. In some neurodegenerative diseases, the suppression of autophagic activity accelerates disease progression. Given that the induction of autophagy can potentially mitigate disease severity, various autophagy-inducing compounds have been developed and their efficacy has been evaluated in several rodent models of neurodegenerative diseases.

引用

页数：11

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