Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature

被引：0

作者：

Hinson, Ashley R. P. ^{[1
,3
]}

Patel, Niraj ^{[2
,3
]}

Kaplan, Joel ^{[1
,3
]}

机构：

[1] Levine Childrens Hosp, Div Pediat Canc & Blood Disorders, Charlotte, NC USA

[2] Levine Childrens Hosp, Div Immunol & Infect Dis, Charlotte, NC USA

[3] Levine Childrens Hosp, Atrium Hlth, Charlotte, NC USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2021年 / 43卷 / 01期

关键词：

HLH; LCH; pediatric; ACTIVATION; EXPRESSION; CHILD;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A toddler undergoing treatment for refractory Langerhans cell histiocytosis (LCH) developed concurrent hemophagocytic lymphohistiocytosis (HLH). These are thought to be distinct histiocytic disorders, with different pathophysiologies, diagnostic criteria, and treatments. HLH in a patient with LCH is thought to be quite rare. In this report, we review the presentation of our patient, as well as review the existing literature of other pediatric patients who have been diagnosed with both LCH and HLH.

引用

页码：24 / 27

页数：4

共 23 条

[1] BRAF and MAP2K1 mutations in Langerhans cell histiocytosis: a study of 50 cases [J].

Alayed, Khaled ;

Medeiros, L. Jeffrey ;

Patel, Keyur P. ;

Zuo, Zhuang ;

Li, Shaoying ;

Verma, Shalini ;

Galbincea, John ;

Cason, R. Craig ;

Luthra, Rajyalakshmi ;

Yin, C. Cameron .

HUMAN PATHOLOGY, 2016, 52 :61-67

[2] How I treat Langerhans cell histiocytosis [J].

Allen, Carl E. ;

Ladisch, Stephan ;

McClain, Kenneth L. .

BLOOD, 2015, 126 (01) :26-35

[3] Cell-Specific Gene Expression in Langerhans Cell Histiocytosis Lesions Reveals a Distinct Profile Compared with Epidermal Langerhans Cells [J].

Allen, Carl E. ;

Li, Liunan ;

Peters, Tricia L. ;

Leung, Hon-Chiu Eastwood ;

Yu, Alexander ;

Man, Tsz-Kwong ;

Gurusiddappa, Sivashankarappa ;

Phillips, Michelle T. ;

Hicks, M. John ;

Gaikwad, Amos ;

Merad, Miriam ;

McClain, Kenneth L. .

JOURNAL OF IMMUNOLOGY, 2010, 184 (08) :4557-4567

[4] Recent advances in the understanding of Langerhans cell histiocytosis [J].

Badalian-Very, Gayane ;

Vergilio, Jo-Anne ;

Degar, Barbara A. ;

Rodriguez-Galindo, Carlos ;

Rollins, Barrett J. .

BRITISH JOURNAL OF HAEMATOLOGY, 2012, 156 (02) :163-172

[5] A Multicenter Study of Patients with Multisystem Langerhans Cell Histiocytosis Who Develop Secondary Hemophagocytic Lymphohistiocytosis [J].

Chellapandian, Deepak ;

Hines, Melissa R. ;

Zhang, Rui ;

Jeng, Michael ;

van den Bos, Cor ;

Santa-Maria Lopez, Vicente ;

Lehmberg, Kai ;

Sieni, Elena ;

Wang, Yini ;

Nakano, Taizo ;

Williams, James A. ;

Fustino, Nicholas J. ;

Astigarraga, Itziar ;

Dunkel, Ira J. ;

Abla, Oussama ;

van Halteren, Astrid G. S. ;

Pei, Deqing ;

Cheng, Cheng ;

Weitzman, Sheila ;

Sung, Lillian ;

Nichols, Kim E. .

CANCER, 2019, 125 (06) :963-971

[6]

Dokmanovic L, 2014, TURKISH J PEDIATR, V56, P452

[7] Macrophage activation and hemophagocytic syndrome in Langerhans cell histiocytosis: Report of 30 cases [J].

Favara, BE ;

Jaffe, R ;

Egeler, RM .

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2002, 5 (02) :130-140

[8] Histiocytic Disorders: Recent Insights into Pathophysiology and Practical Guidelines [J].

Filipovich, Alexandra ;

McClain, Kenneth ;

Grom, Alexei .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (01) :S82-S89

[9] Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis [J].

Fleming, MD ;

Pinkus, JL ;

Alexander, SW ;

Tam, C ;

Loda, M ;

Sallan, SE ;

Nichols, KE ;

Carpentieri, DF ;

Pinkus, GS ;

Rollins, BJ .

BLOOD, 2003, 101 (07) :2473-2475

[10] A Clinicopathologic Review and Molecular Pathogenetic Update [J].

Harmon, Charles M. ;

Brown, Noah .

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2015, 139 (10) :1211-1214

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