Recent advances in the synthesis of antifungal agents

被引：11

作者：

Barrett, AGM ^{[1
]}

Doubleday, WW ^{[1
]}

Hamprecht, D ^{[1
]}

Kasdorf, K ^{[1
]}

Tustin, GJ ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

PURE AND APPLIED CHEMISTRY | 1997年 / 69卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1351/pac199769030383

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

FR-900848 is a pentacyclopropane nucleoside antifungal agent isolated from the fermentation broth of Streptoverticillium fervens. The full structure with relative and absolute stereochemistry of this unusual natural product were established by a combination of partial synthesis and degradation. This assignment was confirmed by total synthesis from (E,E)-2,4-hexadiene-1,6-diol using three sequential asymmetric cyclopropanation reactions, Horner Emmons homologation and selective deoxygenation.

引用

页码：383 / 388

页数：6

共 50 条

[21] RECENT ADVANCES IN ANTIINFECTIVE AGENTS
HAMMOND, ML
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 28, 1993, 28 : 119 - 130
[22] Recent advances in antiviral agents
Shih, SR
CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (11) : 1299 - 1300
[23] RECENT ADVANCES IN ANTIVIRAL AGENTS
RICHMOND, S
LONGSON, M
PRACTITIONER, 1982, 226 (1372) : 1711 - &
[24] Recent Advances in the Use of Cyclodextrins in Antifungal Formulations
Macaev, Fliur
Boldescu, Veaceslav
Geronikaki, Athina
Sucman, Natalia
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 13 (21) : 2677 - 2683
[25] Recent advances in natural antifungal flavonoids and their derivatives
Jin, Yong-Sheng
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (19)
[26] Recent advances in the synthesis and activity of analogues of bistetrahydroisoquinoline alkaloids as antitumor agents
Guo, Ju
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 262
[27] Recent advances in the design and synthesis of heterocycles as anti-tubercular agents
Chauhan, Prem M. S.
Sunduru, Naresh
Sharma, Moni
FUTURE MEDICINAL CHEMISTRY, 2010, 2 (09) : 1469 - 1500
[28] Recent advances in the synthesis of Quinazoline analogues as Anti-TB agents
Dutta, Apurba
Sarma, Diganta
TUBERCULOSIS, 2020, 124
[29] Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance
Mehta, Devashish
Saini, Varsha
Bajaj, Avinash
RSC MEDICINAL CHEMISTRY, 2023, 14 (09): : 1603 - 1628
[30] Recent advances in neuromuscular blocking agents
Zlotos, DP
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (06) : 595 - 606

← 1 2 3 4 5 →