Recent advances in the synthesis of antifungal agents

被引：11

作者：

Barrett, AGM ^{[1
]}

Doubleday, WW ^{[1
]}

Hamprecht, D ^{[1
]}

Kasdorf, K ^{[1
]}

Tustin, GJ ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

PURE AND APPLIED CHEMISTRY | 1997年 / 69卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1351/pac199769030383

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

FR-900848 is a pentacyclopropane nucleoside antifungal agent isolated from the fermentation broth of Streptoverticillium fervens. The full structure with relative and absolute stereochemistry of this unusual natural product were established by a combination of partial synthesis and degradation. This assignment was confirmed by total synthesis from (E,E)-2,4-hexadiene-1,6-diol using three sequential asymmetric cyclopropanation reactions, Horner Emmons homologation and selective deoxygenation.

引用

页码：383 / 388

页数：6

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