Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

被引：54

作者：

Liu, Jie ^{[1
]}

Kurashiki, Kenji ^{[1
]}

Shimizu, Kunlyoshi ^{[1
]}

Kondo, Ryuichiro ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 24期

关键词：

5; alpha-reductase; Ganoderma lucidum; anti-androgen activiities; benign prostatic hyperplasia (BPH);

D O I：

10.1016/j.bmc.2006.08.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In humans, 5 alpha-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5 alpha-reductase activity. The presence of the C-3 carbonyl group and of the C-26-alpha, beta-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8654 / 8660

页数：7

共 51 条

[1] SELECTIVE RETENTION OF DIHYDROTESTO-STERONE BY PROSTATIC NUCLEI [J].

ANDERSON, KM ;

LIAO, S .

NATURE, 1968, 219 (5151) :277-&

[2] STRUCTURAL AND BIOCHEMICAL-PROPERTIES OF CLONED AND EXPRESSED HUMAN AND RAT STEROID 5-ALPHA-REDUCTASES [J].

ANDERSSON, S ;

RUSSELL, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3640-3644

[3] DELETION OF STEROID 5-ALPHA-REDUCTASE 2-GENE IN MALE PSEUDOHERMAPHRODITISM [J].

ANDERSSON, S ;

BERMAN, DM ;

JENKINS, EP ;

RUSSELL, DW .

NATURE, 1991, 354 (6349) :159-161

[4] 3 NEW LANOSTANOIDS FROM GANODERMA-LUCIDUM [J].

ARISAWA, M ;

FUJITA, A ;

SAGA, M ;

FUKUMURA, H ;

HAYASHI, T ;

SHIMIZU, M ;

MORITA, N .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (04) :621-625

[5] SYNTHESIS OF THE INDIVIDUAL ENANTIOMERS OF THE BENZOQUINOLINONE HUMAN TYPE-1 STEROID 5-ALPHA-REDUCTASE INHIBITORS LY191704 AND LY266111 [J].

AUDIA, JE ;

LAWHORN, DE ;

DEETER, JB .

TETRAHEDRON LETTERS, 1993, 34 (44) :7001-7004

[6] METABOLISM OF TESTOSTERONE BY HUMAN MALE SCALP SKIN [J].

BINGHAM, KD ;

SHAW, DA .

JOURNAL OF ENDOCRINOLOGY, 1973, 57 (01) :111-121

[7] PHARMACOLOGICAL INDUCTION OF 5-ALPHA-REDUCTASE DEFICIENCY IN THE RAT - SEPARATION OF TESTOSTERONE-MEDIATED AND 5-ALPHA-DIHYDROTESTOSTERONE-MEDIATED EFFECTS [J].

BLOHM, TR ;

LAUGHLIN, ME ;

BENSON, HD ;

JOHNSTON, JO ;

WRIGHT, CL ;

SCHATZMAN, GL ;

WEINTRAUB, PM .

ENDOCRINOLOGY, 1986, 119 (03) :959-966

[8]

Bonkhoff H, 1996, PROSTATE, V29, P261, DOI 10.1002/(SICI)1097-0045(199610)29:4<261::AID-PROS7>3.0.CO

[9]

2-E

[10] PROSTATIC EFFECTS INDUCED IN DOGS BY CHRONIC OR ACUTE ORAL-ADMINISTRATION OF 5-ALPHA-REDUCTASE INHIBITORS [J].

BROOKS, JR ;

BERMAN, C ;

GARNES, D ;

GILTINAN, D ;

GORDON, LR ;

MALATESTA, PF ;

PRIMKA, RL ;

REYNOLDS, GF ;

RASMUSSON, GH .

PROSTATE, 1986, 9 (01) :65-75

← 1 2 3 4 5 6 →