Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

被引：54
作者：
Liu, Jie [1 ]
Kurashiki, Kenji [1 ]
Shimizu, Kunlyoshi [1 ]
Kondo, Ryuichiro [1 ]
机构：
[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 24期
关键词：
5; alpha-reductase; Ganoderma lucidum; anti-androgen activiities; benign prostatic hyperplasia (BPH);
D O I：
10.1016/j.bmc.2006.08.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In humans, 5 alpha-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5 alpha-reductase activity. The presence of the C-3 carbonyl group and of the C-26-alpha, beta-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：8654 / 8660
页数：7
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