Merobatzelladines A and B, Anti-Infective Tricyclic Guanidines from a Marine Sponge Monanchora sp.

被引：36

作者：

Takishima, Shunsuke ^{[1
]}

Ishiyama, Aki ^{[2
]}

Iwatsuki, Masato ^{[2
]}

Otoguro, Kazuhiko ^{[2
]}

Yamada, Haruki ^{[2
]}

Omura, Satoshi ^{[2
]}

Kobayashi, Hirotsugu ^{[1
]}

van Soest, Rob W. M. ^{[3
]}

Matsunaga, Shigeki ^{[1
]}

机构：

[1] Univ Tokyo, Lab Aquat Nat Prod Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[2] Kitasato Univ, Res Ctr Trop Dis, Kitasato Inst, Kitasato Inst Life Sci,Minato Ku, Tokyo 1088641, Japan

[3] Univ Amsterdam, Zool Museum, NL-1090 GT Amsterdam, Netherlands

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 12期

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; BATZELLADINE-F; STRUCTURAL REVISION; ALKALOIDS; STEREOCHEMISTRY; METABOLITES; HIV-1;

D O I：

10.1021/ol9006794

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Merobatzelladines A (1) and B (2) have been isolated from a marine sponge Monanchora sp. as antibacterial constituents. Their structures including relative stereochemistry were determined by interpretation of spectral data. The absolute stereochemistry of merobatzelladine B (2) was elucidated after introduction of the fourth ring system preinstalled with a secondary hydroxyl group to which the modified Mosher method was applied. Merobatzelladines exhibit moderate anti-infective activity against a bacterium and protozoa.

引用

页码：2655 / 2658

页数：4

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