Light-controlled reactive oxygen species (ROS)-producible polymeric micelles with simultaneous drug-release triggering and endo/lysosomal escape

被引:61
作者
Kim, Kihong [1 ]
Lee, Chung-Sung [1 ]
Na, Kun [1 ]
机构
[1] Catholic Univ Korea, Dept Biotechnol, 43 Jibong Ro, Bucheon Si 420743, Gyeonggi Do, South Korea
基金
新加坡国家研究基金会;
关键词
COMPLEX VESICLES; DELIVERY; NANOPARTICLES; CANCER; PHOTOSENSITIZER; NANOMEDICINE; CHEMOTHERAPY; COPOLYMERS; OXIDATION; PPS;
D O I
10.1039/c5cc09239f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A doxorubicin (DOX)-loaded and light-induced ROS-producing polymeric micelle (D-LRPM), in which light triggers simultaneous DOX-release and endo/lysosomal escape, produces a powerful, spatiotemporally controllable, therapeutic efficacy for tumor treatment.
引用
收藏
页码:2839 / 2842
页数:4
相关论文
共 29 条
  • [1] Oxidation of thiols to disulfides with molecular bromine on hydrated silica gel support
    Ali, MH
    McDermott, M
    [J]. TETRAHEDRON LETTERS, 2002, 43 (35) : 6271 - 6273
  • [2] Berg K, 1999, CANCER RES, V59, P1180
  • [3] Ultra-sensitive ROS-responsive tellurium-containing polymers
    Cao, Wei
    Gu, Yuwei
    Li, Tianyu
    Xu, Huaping
    [J]. CHEMICAL COMMUNICATIONS, 2015, 51 (32) : 7069 - 7071
  • [4] PEG-SS-PPS: Reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery
    Cerritelli, Simona
    Velluto, Diana
    Hubbell, Jeffrey A.
    [J]. BIOMACROMOLECULES, 2007, 8 (06) : 1966 - 1972
  • [5] Polyion Complex Vesicles for Photoinduced Intracellular Delivery of Amphiphilic Photosensitizer
    Chen, Huabing
    Xiao, Ling
    Anraku, Yasutaka
    Mi, Peng
    Liu, Xueying
    Cabral, Horacio
    Inoue, Aki
    Nomoto, Takahiro
    Kishimura, Akihiro
    Nishiyama, Nobuhiro
    Kataoka, Kazunori
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (01) : 157 - 163
  • [6] Noncovalent interaction-assisted polymeric micelles for controlled drug delivery
    Ding, Jianxun
    Chen, Linghui
    Xiao, Chunsheng
    Chen, Li
    Zhuang, Xiuli
    Chen, Xuesi
    [J]. CHEMICAL COMMUNICATIONS, 2014, 50 (77) : 11274 - 11290
  • [7] Cell Protective, ABC Triblock Polymer-Based Thermoresponsive Hydrogels with ROS-Triggered Degradation and Drug Release
    Gupta, Mukesh K.
    Martin, John R.
    Werfel, Thomas A.
    Shen, Tianwei
    Page, Jonathan M.
    Duvall, Craig L.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (42) : 14896 - 14902
  • [8] Photochemically Triggered Cytosolic Drug Delivery Using pH-Responsive Hyaluronic Acid Nanoparticles for Light-Induced Cancer Therapy
    Lee, Chung-Sung
    Na, Kun
    [J]. BIOMACROMOLECULES, 2014, 15 (11) : 4228 - 4238
  • [9] Endolysosomal environment-responsive photodynamic nanocarrier to enhance cytosolic drug delivery via photosensitizer-mediated membrane disruption
    Lee, Chung-Sung
    Park, Wooram
    Park, Sin-jung
    Na, Kun
    [J]. BIOMATERIALS, 2013, 34 (36) : 9227 - 9236
  • [10] Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly (ethylene glycol)-b-poly(L-histidine)
    Lee, Eun Seong
    Oh, Kyung Taek
    Kim, Dongin
    Youn, Yu Seok
    Bae, You Han
    [J]. JOURNAL OF CONTROLLED RELEASE, 2007, 123 (01) : 19 - 26