Two nested developmental waves demarcate a compartment boundary in the mouse lung

被引:87
作者
Alanis, Denise Martinez [1 ]
Chang, Daniel R. [1 ]
Akiyama, Haruhiko [2 ]
Krasnow, Mark A. [3 ,4 ]
Chen, Jichao [1 ,3 ,4 ,5 ,6 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Pulm Med, Houston, TX 77030 USA
[2] Kyoto Univ, Dept Orthoped, Sakyo Ku, Kyoto 6068507, Japan
[3] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA
[4] Stanford Univ, HHMI, Sch Med, Stanford, CA 94305 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA
[6] Univ Texas MD Anderson Canc Ctr, Ctr Stem Cells & Dev Biol, Houston, TX 77030 USA
关键词
GLUCOCORTICOID-RECEPTOR GENE; CONDITIONAL EXPRESSION; BRANCHING PROGRAM; MULTIPLE ROLES; STEM-CELLS; ALVEOLAR; SOX2; MAINTENANCE; MATURATION; ORIGIN;
D O I
10.1038/ncomms4923
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The lung is a branched tubular network with two distinct compartments-the proximal conducting airways and the peripheral gas exchange region-separated by a discrete boundary termed the bronchoalveolar duct junction (BADJ). Here we image the developing mouse lung in three-dimensions (3D) and show that two nested developmental waves demarcate the BADJ under the control of a global hormonal signal. A first wave of branching morphogenesis progresses throughout embryonic development, generating branches for both compartments. A second wave of conducting airway differentiation follows the first wave but terminates earlier, specifying the proximal compartment and setting the BADJ. The second wave is terminated by a glucocorticoid signalling: premature activation or loss of glucocorticoid signalling causes a proximal or distal shift, respectively, in BADJ location. The results demonstrate a new mechanism of boundary formation in complex, 3D organs and provide new insights into glucocorticoid therapies for lung defects in premature birth.
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页数:15
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