SZGR 2.0: a one-stop shop of schizophrenia candidate genes

被引：29

作者：

Jia, Peilin ^{[1
]}

Han, Guangchun ^{[1
]}

Zhao, Junfei ^{[1
]}

Lu, Pinyi ^{[1
]}

Zhao, Zhongming ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Ctr Precis Hlth, Houston, TX 77030 USA

[2] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; QUANTITATIVE TRAIT LOCI; DNA METHYLATION; RISK LOCI; EXPRESSION; VARIANTS; TRANSCRIPTOME; DATABASE; BRAIN; METAANALYSIS;

D O I：

10.1093/nar/gkw902

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational and many other types of evidence. By systematic review and curation of multiple lines of evidence, we included almost all variants and genes that have ever been reported to be associated with schizophrenia. In particular, we collected similar to 4200 common variants reported in genome-wide association studies, similar to 1000 de novo mutations discovered by large-scale sequencing of family samples, 215 genes spanning rare and replication copy number variations, 99 genes overlapping with linkage regions, 240 differentially expressed genes, 4651 differentially methylated genes and 49 genes as antipsychotic drug targets. To facilitate interpretation, we included various functional annotation data, especially brain eQTL, methylation QTL, brain expression featured in deep categorization of brain areas and developmental stages and brain- specific promoter and enhancer annotations. Furthermore, we conducted cross-study, cross-data type and integrative analyses of the multidimensional data deposited in SZGR 2.0, and made the data and results available through a user-friendly interface. In summary, SZGR 2.0 provides a one-stop shop of schizophrenia variants and genes and their function and regulation, providing an important resource in the schizophrenia and other mental disease community. SZGR 2.0 is available at https: //bioinfo.uth.edu/SZGR/.

引用

页码：D915 / D924

页数：10

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