Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia

被引：30

作者：

Pongstaporn, W. ^{[2
]}

Pakakasama, S. ^{[3
]}

Sanguansin, S. ^{[4
]}

Hongeng, S. ^{[3
]}

Petmitr, Songsak ^{[1
]}

机构：

[1] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, Bangkok 10400, Thailand

[2] Rangsit Univ, Fac Med Technol, Pathum Thani, Thailand

[3] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Pediat, Bangkok 10400, Thailand

[4] Mahidol Univ, Fac Dent, Dept Physiol & Biochem, Bangkok 10400, Thailand

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2009年 / 135卷 / 05期

关键词：

Acute lymphoblastic leukemia (ALL); Glutathione S-transferase Omega; Gene polymorphism; METABOLIZING-ENZYMES; CANCER PATIENTS; OVARIAN-CANCER; SUSCEPTIBILITY; GENOTYPES; CHILDREN; FAMILY; GLUTATHIONE-S-TRANSFERASE-OMEGA-2; DISEASE;

D O I：

10.1007/s00432-008-0501-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose To evaluate the association between glutathione S-transferase Omega (GSTO) genes polymorphism and the susceptibility of acute lymphoblast leukemia (ALL). Methods The polymorphism of GSTO1 and GSTO2 genes were analyzed in 99 ALL patients compared with 100 healthy children by PCR-based restriction fragment length polymorphism (RFLP) analysis. Results GSTO1*A140D polymorphism was significantly associated with susceptibility to ALL (OR = 2.24, 95% CI = 1.16-4.35, P = 0.009) whereas, GSTO2*N142D genotype was significantly interacted with high risk group of childhood ALL (OR = 5.52, 95% CI = 1.72-17.71, P = 0.004). Conclusion This study revealed gene polymorphism in glutathione S-transferase Omega class may be a risk factor to the development of acute childhood lymphoblastic leukemia.

引用

页码：673 / 678

页数：6

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