Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia

被引：30
|
作者：
Pongstaporn, W. [2 ]
Pakakasama, S. [3 ]
Sanguansin, S. [4 ]
Hongeng, S. [3 ]
Petmitr, Songsak [1 ]
机构：
[1] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, Bangkok 10400, Thailand
[2] Rangsit Univ, Fac Med Technol, Pathum Thani, Thailand
[3] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Pediat, Bangkok 10400, Thailand
[4] Mahidol Univ, Fac Dent, Dept Physiol & Biochem, Bangkok 10400, Thailand
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2009年 / 135卷 / 05期
关键词：
Acute lymphoblastic leukemia (ALL); Glutathione S-transferase Omega; Gene polymorphism; METABOLIZING-ENZYMES; CANCER PATIENTS; OVARIAN-CANCER; SUSCEPTIBILITY; GENOTYPES; CHILDREN; FAMILY; GLUTATHIONE-S-TRANSFERASE-OMEGA-2; DISEASE;
D O I：
10.1007/s00432-008-0501-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose To evaluate the association between glutathione S-transferase Omega (GSTO) genes polymorphism and the susceptibility of acute lymphoblast leukemia (ALL). Methods The polymorphism of GSTO1 and GSTO2 genes were analyzed in 99 ALL patients compared with 100 healthy children by PCR-based restriction fragment length polymorphism (RFLP) analysis. Results GSTO1*A140D polymorphism was significantly associated with susceptibility to ALL (OR = 2.24, 95% CI = 1.16-4.35, P = 0.009) whereas, GSTO2*N142D genotype was significantly interacted with high risk group of childhood ALL (OR = 5.52, 95% CI = 1.72-17.71, P = 0.004). Conclusion This study revealed gene polymorphism in glutathione S-transferase Omega class may be a risk factor to the development of acute childhood lymphoblastic leukemia.
引用
收藏
页码：673 / 678
页数：6
相关论文
共 50 条
  • [1] Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia
    W. Pongstaporn
    S. Pakakasama
    S. Sanguansin
    S. Hongeng
    Songsak Petmitr
    Journal of Cancer Research and Clinical Oncology, 2009, 135 : 673 - 678
  • [2] Polymorphism of glutathione S-transferase omega gene and risk of cancer
    Marahatta, Sujan Babu
    Punyarit, Phaibul
    Bhudisawasdi, Vajarabhongsa
    Paupairoj, Anucha
    Wongkham, Sopit
    Petmitr, Songsak
    CANCER LETTERS, 2006, 236 (02) : 276 - 281
  • [3] The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a case-control study
    Marianne E. Yassa
    Hanaa H. Arnaout
    Shahira K. Botros
    Emad N. Obaid
    Wael M. Mahmoud
    Dalia S. Morgan
    Egyptian Journal of Medical Human Genetics, 22
  • [4] The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a case-control study
    Yassa, Marianne E.
    Arnaout, Hanaa H.
    Botros, Shahira K.
    Obaid, Emad N.
    Mahmoud, Wael M.
    Morgan, Dalia S.
    EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS, 2021, 22 (01)
  • [5] Childhood Pre-B acute lymphoblastic leukemia and glutathione S-transferase omega 1 and 2 polymorphisms
    Rezazadeh, D.
    Moradi, M. -T.
    Kazemi, A.
    Mansouri, K.
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2015, 37 (04) : 530 - 535
  • [6] Genotypes of the glutathione S-transferase superfamily do not correlate with outcome of childhood acute lymphoblastic leukemia
    Alessandra Sala
    Marina Lanciotti
    Maria Grazia Valsecchi
    Paola di Michele
    Carlo Dufour
    Riccardo Haupt
    Giuseppe Basso
    Carmelo Rizzari
    Andrea Biondi
    Leukemia, 2003, 17 : 981 - 983
  • [7] Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia
    Davies, SM
    Bhatia, S
    Ross, JA
    Kiffmeyer, WR
    Gaynon, PS
    Radloff, GA
    Robison, LL
    Perentesis, JP
    BLOOD, 2002, 100 (01) : 67 - 71
  • [8] Genotypes of the glutathione S-transferase superfamily do not correlate with outcome of childhood acute lymphoblastic leukemia
    Sala, A
    Lanciotti, M
    Valsecchi, MG
    di Michele, P
    Dufour, C
    Haupt, G
    Rizzari, C
    Biondi, A
    LEUKEMIA, 2003, 17 (05) : 981 - 983
  • [9] Impact of glutathione S-transferase gene deletion on early relapse in childhood B-precursor acute lymphoblastic leukemia
    Takanashi, M
    Morimoto, A
    Yagi, T
    Kuriyama, K
    Kano, G
    Imamura, T
    Hibi, S
    Todo, S
    Imashuku, S
    HAEMATOLOGICA, 2003, 88 (11) : 1238 - 1244
  • [10] Polymorphism within glutathione S-transferase genes in childhood acute lymphoblastic leukemia:: Results of three case-control studies
    Stanulla, M
    Anderer, G
    Arens, S
    Müller, BA
    Welte, K
    Schrappe, M
    LEUKEMIA, 2001, 15 (03) : 495 - 495
12345