The CART gene: Structure and regulation

被引：39

作者：

Dominguez, Geraldina ^{[1
]}

机构：

[1] Emory Univ, Yerkes Natl Primate Ctr, Div Neurosci, Atlanta, GA 30329 USA

来源：

PEPTIDES | 2006年 / 27卷 / 08期

关键词：

CART gene; promoter; CREB; CRE; PKA; cocaine;

D O I：

10.1016/j.peptides.2006.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CART peptides are important neuropeptides that are involved in a variety of physiologic processes. The regulation of the CART gene is critical since peptides are regulated and secreted in response to specific stimuli. CART mRNA must also be controlled in order to respond to specific stimuli such as psychostimulant drugs and leptin. The regulation of the CART gene is central to maintaining homeostasis of peptide production. The 5' upstream region of the CART gene contains powerful regulatory elements that must be involved in transcriptional regulation via different signaling pathways. This review touches on several aspects related to CART gene regulation such as: (i) CART genomic structure, (ii) stimuli that alter CART mRNA levels, (iii) promoter characterization, (iv) role of the cAMP/PKA/CREB signal transduction pathway, and (v) role of the CART 5' and 3' ends in CART mRNA regulation. The goal of this review is to present current data so as to encourage further work in the field of CART gene regulation. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1913 / 1918

页数：6

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