A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats

被引：41

作者：

Gu, Liqiang ^{[1
]}

Wang, Xiaofan ^{[1
]}

Liu, Zhenzhen ^{[1
]}

Ju, Ping ^{[1
]}

Zhang, Lunhui ^{[1
]}

Zhang, Yuanyuan ^{[1
]}

Ma, Bingjie ^{[1
]}

Bi, Kaishun ^{[1
]}

Chen, Xiaohui ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 68卷

关键词：

Semen Strychni; Strychnine; Brucine; Kidney injury; Herb-herb interaction; Toxicokinetic; IN-VITRO METABOLISM; NUX-VOMICA; LIPID-PEROXIDATION; P-GLYCOPROTEIN; CELL-LINE; N-OXIDE; LIGUSTRAZINE; ALKALOIDS; TOXICITY; LICORICE;

D O I：

10.1016/j.fct.2014.03.028

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Recently, the renal injury caused by Semen strychni and its major toxic constituents, strychnine and brucine, was reported in many clinical cases. Hence, this study was conducted to investigate the renal injury induced by Semen Strychni and the protective effects of Radix Glycyrrhizae and Rhizoma Ligustici. The protective mechanisms were related to the comparative toxicokinetics of strychnine and brucine. Serum and urine uric acid and creatinine were used as renal function markers to evaluate the condition of kidney, and renal injury was directly reflected by histopathological changes: Compared with rats in blank group and protective herb groups, rats in Semen Strychni high-dose group showed significant differences in the results of renal function markers, and various glomerular and tubular degenerations were found in the histopathological study. The decreased AUC (only strychnine) and C-max, the increased T-max by Radix Glycyrrhizae and the decreased T-1/2 by Radix Glycyrrhizae and Rhizoma Ligustici were found in model groups. Results indicated that high dose of Semen Strychni might induce renal injury. Radix Glycyrrhizae and Rhizome Ligustici might work together and have effects on the elimination of strychnine and brucine. The protective effects of Radix Glycyrrhizae might also be explained by the slow absorption of the alkaloids. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：226 / 233

页数：8

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