To live or die by the sword: The regulation of apoptosis by the proteasome

被引：31

作者：

Friedman, J ^{[1
]}

Xue, D ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

DEVELOPMENTAL CELL | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1534-5807(04)00104-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proteasome has been implicated in the control of apoptosis by modulating the levels of both pro- and antiapoptotic molecules. A recent study published in the April 9th issue of Molecular Cell reveals that caspase-dependent inactivation of the proteasome can amplify the activation of apoptosis.

引用

页码：460 / 461

页数：2

共 9 条

[1] Regulators of IAP function: coming to grips with the grim reaper [J].

Bergmann, A ;

Yang, AYP ;

Srivastava, M .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (06) :717-724

[2] Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition [J].

Du, CY ;

Fang, M ;

Li, YC ;

Li, L ;

Wang, XD .

CELL, 2000, 102 (01) :33-42

[3] The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction [J].

Glickman, MH ;

Ciechanover, A .

PHYSIOLOGICAL REVIEWS, 2002, 82 (02) :373-428

[4] Deadly encounter: Ubiquitin meets apoptosis [J].

Jesenberger, V ;

Jentsch, S .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (02) :112-121

[5] Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation [J].

Nijhawan, D ;

Fang, M ;

Traer, E ;

Zhong, Q ;

Gao, WH ;

Du, FH ;

Wang, XD .

GENES & DEVELOPMENT, 2003, 17 (12) :1475-1486

[6] Caspase activation inhibits proteasome, function during apoptosis [J].

Sun, XM ;

Butterworth, M ;

MacFarlane, M ;

Dubiel, W ;

Ciechanover, A ;

Cohen, GM .

MOLECULAR CELL, 2004, 14 (01) :81-93

[7] Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death [J].

Suzuki, Y ;

Nakabayashi, Y ;

Takahashi, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8662-8667

[8] Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins [J].

Verhagen, AM ;

Ekert, PG ;

Pakusch, M ;

Silke, J ;

Connolly, LM ;

Reid, GE ;

Moritz, RL ;

Simpson, RJ ;

Vaux, DL .

CELL, 2000, 102 (01) :43-53

[9] Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli [J].

Yang, Y ;

Fang, SY ;

Jensen, JP ;

Weissman, AM ;

Ashwell, JD .

SCIENCE, 2000, 288 (5467) :874-877

← 1 →