Biomarkers for physical frailty and sarcopenia: state of the science and future developments

被引：206

作者：

Calvani, Riccardo ^{[1
]}

Marini, Federico ^{[2
]}

Cesari, Matteo ^{[3
,4
]}

Tosato, Matteo ^{[1
]}

Anker, Stefan D. ^{[5
]}

von Haehling, Stephan ^{[5
]}

Miller, Ram R. ^{[6
]}

Bernabei, Roberto ^{[1
]}

Landi, Francesco ^{[1
]}

Marzetti, Emanuele ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Geriatr Neurosci & Orthoped, I-00168 Rome, Italy

[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[3] Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France

[4] Univ Toulouse 3, INSERM, UMR1027, F-31062 Toulouse, France

[5] Univ Med Ctr Gottingen UMG, Dept Innovat Clin Trials, Gottingen, Germany

[6] GlaxoSmithKline R&D, Metab Pathways & Cardiovasc Therapeut Area, Muscle Metab Discovery Performance Unit, Res Triangle Pk, NC USA

来源：

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | 2015年 / 6卷 / 04期

关键词：

Ageing; Disability; Physical performance; Circulating markers; Imaging; Multivariate modelling; TERMINAL AGRIN FRAGMENT; LOWER-EXTREMITY FUNCTION; SKELETAL-MUSCLE; OLDER-ADULTS; INFLAMMATORY MARKERS; GRIP STRENGTH; NEUROMUSCULAR-JUNCTION; MOBILITY LIMITATION; NUTRITIONAL-STATUS; METABOLOMICS DATA;

D O I：

10.1002/jcsm.12051

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Physical frailty and sarcopenia are two common and largely overlapping geriatric conditions upstream of the disabling cascade. The lack of a unique operational definition for physical frailty and sarcopenia and the complex underlying pathophysiology make the development of biomarkers for these conditions extremely challenging. Indeed, the current definitional ambiguities of physical frailty and sarcopenia, together with their heterogeneous clinical manifestations, impact the accuracy, specificity, and sensitivity of individual biomarkers proposed so far. In this review, the current state of the art in the development of biomarkers for physical frailty and sarcopenia is presented. A novel approach for biomarker identification and validation is also introduced that moves from the 'one fits all' paradigm to a multivariate methodology.

引用

页码：278 / 286

页数：9

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